{"created":"2023-06-19T11:23:27.724342+00:00","id":4003,"links":{},"metadata":{"_buckets":{"deposit":"73ee3104-75f0-4235-95f3-9c4c6c2034d5"},"_deposit":{"created_by":3,"id":"4003","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4003"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004003","sets":["7","7:24"]},"author_link":["12070","12071","12072","12073","12074","12075","12076","12077","12078","12079","12080","12081"],"control_number":"4003","item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"205","bibliographicPageStart":"200","bibliographicVolumeNumber":"415","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lipin-1 plays a crucial role in the regulation of lipid metabolism and cell differentiation in adipocytes. Expression of adipose lipin-1 is reduced in obesity, and metabolic syndrome. However, the significance of this reduction remains unclear. This study investigated if and how reduced lipin-1 expression affected metabolism. We assessed mRNA expression levels of various genes related to adipocyte metabolism in lipin-1-depleted 3T3-L1 adipocytes by introducing its specific small interfering RNA. In lipin-1-depleted adipocytes, mRNA and protein expression levels of monocyte chemoattractant protein-1 (MCP-1) were significantly increased, although the other genes tested were not altered. The conditioned media from the cells promoted monocyte chemotaxis. The increase in MCP-1 expression was prevented by treatment with quinazoline or salicylate, inhibitors of nuclear factor-κB activation. Because MCP-1 is related to adipose inflammation and systemic insulin resistance, these results suggest that a reduction in adipose lipin-1 in obesity may exacerbate adipose inflammation and metabolism.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1016/j.bbrc.2011.10.060","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2011.10.060","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"22033411"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"994"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"978"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 伸彦","creatorNameLang":"ja"},{"creatorName":"タカハシ, ノブヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"12070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshizaki, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiranaka, Natsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Tomoo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akanuma, Masayasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oka, Kazuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanazawa, Kaoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Mika","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naito, Sumiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujiya, Mikihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohgo, Yutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ieko, Masahiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4462.pdf","filesize":[{"value":"567.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4462.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4003/files/4462.pdf"},"version_id":"76dd4f7c-c0fd-4436-b1ad-bb51abe761ca"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-05-17"},"publish_date":"2012-05-17","publish_status":"0","recid":"4003","relation_version_is_last":true,"title":["Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-31T05:36:28.524461+00:00"}