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Novel perspectives in probiotic treatment : the efficacy and unveiled mechanisms of the physiological functions

https://asahikawa-med.repo.nii.ac.jp/records/3987
https://asahikawa-med.repo.nii.ac.jp/records/3987
4315177f-52ac-4a98-a3ab-d149b81f3574
名前 / ファイル ライセンス アクション
4545.pdf 4545.pdf (251.1 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2012-05-17
タイトル
タイトル Novel perspectives in probiotic treatment : the efficacy and unveiled mechanisms of the physiological functions
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 藤谷, 幹浩

× 藤谷, 幹浩

ja 藤谷, 幹浩

ja-Kana フジヤ, ミキヒロ

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Kohgo, Yutaka

× Kohgo, Yutaka

en Kohgo, Yutaka

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書誌情報 Clinical Journal of Gastroenterology

巻 3, 号 3, p. 117-127, 発行日 2010-06-01
ISSN
収録物識別子タイプ PISSN
収録物識別子 1865-7257
DOI
識別子タイプ DOI
関連識別子 10.1007/s12328-010-0154-0
リンクURL
内容記述タイプ Other
内容記述 The original publication is available at www.springerlink.com. | The original publication is available at www.springerlink.com.
抄録
内容記述タイプ Abstract
内容記述 Probiotics are defined as “live microorganisms which confer a health benefit on the host” when administered in adequate amounts, and have potential effects for maintaining intestinal development, nutrition, and treating intestinal inflammations, functional disorders, and other extra-intestinal diseases. Although the benefits of probiotics for human health were first noted over 100 years ago, the analysis of probiotic functions began in earnest only 20 years ago. Probiotics, such as some strains of Lactobacillus, Bifidobacterium, Escherichia coli, and Bacillus subtilis, inhibit the growth of pathogenic bacteria, induce competitive effects for the adherent of pathogenic bacteria and their toxins to intestinal epithelia, induce cytoprotective heat shock proteins, enhance the intestinal barrier function, and modulate the host immune responses. The crosstalk between the host and the probiotics appears to be mediated by bacteria-derived effectors, which can be sensed with multiple systems, including the Toll-like receptors and cell membrane transporters. Future analyses will identify more probiotic-derived effectors, the recognition mechanisms of these effectors, and the subsequent changes of the intestinal epithelia and immune cells for each probiotic treatment. For clinical use, a procedure that objectively evaluates the ability of each probiotic effect will help establish a standard for choosing the most valuable strain and its proper dose for each individual patient.
言語 en
注記
内容記述タイプ Other
注記 http://dx.doi.org/10.1007/s12328-010-0154-0
資源タイプ
内容記述タイプ Other
資源タイプ text
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出版タイプ AM
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内容記述タイプ Other
内容記述 application/pdf
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