| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-04-12 |
| タイトル |
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タイトル |
Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
本村, 亘
Tanno, S
Takahashi, N
Nagamine, M
Fukuda(Sawamukai), M
Kohgo, Y
Okumura, T
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| 著者 ローマ字 |
|
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Motomura, Wataru |
| 書誌情報 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
巻 332,
号 1,
p. 89-94,
発行日 2005-06-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006-291X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.bbrc.2005.04.095 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/0006291X | http://www.sciencedirect.com/science/journal/0006291X |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In the present study, we examined a role of mitogen-activated protein kinases (MAPKs), extracellular signal releted kinase (ERK), c-Jun N-terminal protein kinase (JNK) and p38 MAPK in troglitazone-induced inhibition of cell growth in human pancreatic cancer cells. Among the three kinases, troglitazone specifically inhibited the phosphorylation of ERK1/2 in a dose- and time-dependent manner. Troglitazone also down-regulated the protein expression of mitogen-activated protein kinase kinase (MEK)1/2, an upstream molecule that regulates ERK phosphorylation. Treatment of human pancreatic cancer cells with specific MEK inhibitor, PD98059 or U0126 inhibited ERK1/2 phosphorylation and cell growth. These results suggest for the first time that the inhibition of the MEK1/2-ERK1/2 signaling pathway may be implicated in the growth inhibitory effect by troglitazone in human pancreatic cancer cells. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Elsevier Inc., Wataru Motomura, Satoshi Tanno, Nobuhiko Takahashi, Miho Nagamine, Mitsuko Fukuda (Sawamukai), Yutaka Kohgo and Toshikatsu Okumura, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 332(1), 2005, 89-94.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15896303 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1269 |
438.pdf (321.6 kB)
