{"created":"2023-06-19T11:20:19.520612+00:00","id":348,"links":{},"metadata":{"_buckets":{"deposit":"b4c222d1-a7bd-44b7-ba4d-ac27e87bc71e"},"_deposit":{"created_by":3,"id":"348","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"348"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000348","sets":["7","7:24"]},"author_link":["750","751","752","753","754","755","756"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"94","bibliographicPageStart":"89","bibliographicVolumeNumber":"332","bibliographic_titles":[{"bibliographic_title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/0006291X | http://www.sciencedirect.com/science/journal/0006291X","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the present study, we examined a role of mitogen-activated protein kinases (MAPKs), extracellular signal releted kinase (ERK), c-Jun N-terminal protein kinase (JNK) and p38 MAPK in troglitazone-induced inhibition of cell growth in human pancreatic cancer cells.  Among the three kinases, troglitazone specifically inhibited the phosphorylation of ERK1/2 in a dose- and time-dependent manner.  Troglitazone also down-regulated the protein expression of mitogen-activated protein kinase kinase (MEK)1/2, an upstream molecule that regulates ERK phosphorylation.  Treatment of human pancreatic cancer cells with specific MEK inhibitor, PD98059 or  U0126 inhibited  ERK1/2 phosphorylation and cell growth.  These results suggest for the first time that the inhibition of the MEK1/2-ERK1/2 signaling pathway may be implicated in the growth inhibitory effect by troglitazone in human pancreatic cancer cells.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Elsevier Inc., Wataru Motomura, Satoshi Tanno, Nobuhiko Takahashi, Miho Nagamine,  Mitsuko Fukuda (Sawamukai), Yutaka Kohgo and Toshikatsu Okumura, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 332(1), 2005, 89-94.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2005.04.095","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"15896303"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2625"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1269"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Motomura, Wataru"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本村, 亘"},{"creatorName":"モトムラ, ワタル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanno, S"}],"nameIdentifiers":[{"nameIdentifier":"751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, N"}],"nameIdentifiers":[{"nameIdentifier":"752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagamine, M"}],"nameIdentifiers":[{"nameIdentifier":"753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuda(Sawamukai), M"}],"nameIdentifiers":[{"nameIdentifier":"754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohgo, Y"}],"nameIdentifiers":[{"nameIdentifier":"755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumura, T"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"438.pdf","filesize":[{"value":"321.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"438.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/348/files/438.pdf"},"version_id":"14fdfa16-1817-4206-a817-073d182edf7c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-04-12"},"publish_date":"2007-04-12","publish_status":"0","recid":"348","relation_version_is_last":true,"title":["Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:20:11.958788+00:00"}