WEKO3
-
RootNode
アイテム
TNF-α induced RANTES chemokine expression via activation of NF-kB and p38 MAP kinase: roles of TNF-α in alcoholic liver diseases
https://asahikawa-med.repo.nii.ac.jp/records/215
https://asahikawa-med.repo.nii.ac.jp/records/21599211f80-261c-4466-bfc1-0d0eced1e668
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
256.pdf (464.1 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2007-02-27 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | TNF-α induced RANTES chemokine expression via activation of NF-kB and p38 MAP kinase: roles of TNF-α in alcoholic liver diseases | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
平野, 史倫
× 平野, 史倫
× Komura, K
× Fukawa, E
× Makino, I
|
|||||||||||||||
| 著者 ローマ字 | ||||||||||||||||
| Hirano, Fuminori | ||||||||||||||||
| 書誌情報 |
JOURNAL OF HEPATOLOGY 巻 38, 号 4, p. 483-489, 発行日 2003-04-01 |
|||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 0168-8278 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1016/S0168-8278(02)00456-7 | |||||||||||||||
| リンクURL | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278 | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Background/Aims: Increased concentration of plasma TNF-α correlates with the clinical course of alcoholic liver diseases. In addition, hepatic RANTES which migrates CD4 T lymphocytes to liver is increased in patients with alcoholic hepatitis. We investigated that roles of TNF -α on RANTES expression in hepatocytes. Methods: HLE cells were treated with TNF-α in the presence, or absence of several inhibitors. Enzyme-linked immunoassay and reverse transcriptase-polymerase chain reaction were performed for the measurement of protein production and mRNA of RANTES, respectively. Moreover, DNA-binding activity of NF-kB was investigated using electrophoretic mobility shift assay. To exam effects of TNF-α on RANTES gene expression, luciferase assay was performed. Results: TNF-α clearly up-regulated RANTES expression in a time-dependent fashion and induced DNA-binding activity of NF-kB. Moreover, TNF-α -induced RANTES expression was completely inhibited by SB203580, but not calphostin C and wortmannin. Luciferase assay showed that TNF-α increased RANTES gene expression and mutation of NF-kB binding sites in the RANTES promoter ablated TNF-α inducibility. Conclusions: We presented that RANTES was transcriptionally induced in human hepatoma cells by treatment with TNF-α via activation of NF-kB and p38 MAP kinase, presumably suggesting that TNF-α-induced expression of RANTES plays important roles in cell-mediated liver injury in alcoholic liver diseases. | |||||||||||||||
| 注記 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 注記 | ELSEVIER, Hirano, F; Komura, K; Fukawa, E; Makino, I, JOURNAL OF HEPATOLOGY, 38(4), 483-489, 2003. \nauthor |
|||||||||||||||
| 資源タイプ | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 資源タイプ | text | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| フォーマット | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||
| ID(XooNIps) | ||||||||||||||||
| 12663241 | ||||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||||
| 866 | ||||||||||||||||
Share
Cite as
平野, 史倫, Komura, K, Fukawa, E, Makino, I, n.d., TNF-α induced RANTES chemokine expression via activation of NF-kB and p38 MAP kinase: roles of TNF-α in alcoholic liver diseases: 483–489 p.
Loading...
