{"created":"2023-06-19T11:20:11.970967+00:00","id":215,"links":{},"metadata":{"_buckets":{"deposit":"058d60ff-9feb-4cdf-8a2c-ee61d3248458"},"_deposit":{"created_by":3,"id":"215","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"215"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000215","sets":["7","7:24"]},"author_link":["265","266","267","268"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"489","bibliographicPageStart":"483","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF HEPATOLOGY"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/01688278 | http://www.sciencedirect.com/science/journal/01688278","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aims: Increased concentration of plasma TNF-α correlates with the clinical course of alcoholic liver diseases. In addition, hepatic RANTES which migrates CD4 T lymphocytes to liver is increased in patients with alcoholic hepatitis. We investigated that roles of TNF -α on RANTES expression in hepatocytes.　Methods: HLE cells were treated with TNF-α in the presence, or absence of several inhibitors. Enzyme-linked immunoassay and reverse transcriptase-polymerase chain reaction were performed for the measurement of protein production and mRNA of RANTES, respectively. Moreover, DNA-binding activity of NF-kB was investigated using electrophoretic mobility shift assay. To exam effects of TNF-α on RANTES gene expression, luciferase assay was performed. Results: TNF-α clearly up-regulated RANTES expression in a time-dependent fashion and induced DNA-binding activity of NF-kB. Moreover, TNF-α -induced RANTES expression was completely inhibited by SB203580, but not calphostin C and wortmannin. Luciferase assay showed that TNF-α increased RANTES gene expression and mutation of NF-kB binding sites in the RANTES promoter ablated TNF-α inducibility.　Conclusions: We presented that RANTES was transcriptionally induced in human hepatoma cells by treatment with TNF-α via activation of NF-kB and p38 MAP kinase, presumably suggesting that TNF-α-induced expression of RANTES plays important roles in cell-mediated liver injury in alcoholic liver diseases.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"ELSEVIER, Hirano, F; Komura, K; Fukawa, E; Makino, I, JOURNAL OF HEPATOLOGY, 38(4), 483-489, 2003.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0168-8278(02)00456-7","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0168-8278","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"12663241"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2805"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"866"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Hirano, Fuminori"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平野, 史倫"},{"creatorName":"ヒラノ, フミノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komura, K"}],"nameIdentifiers":[{"nameIdentifier":"266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukawa, E"}],"nameIdentifiers":[{"nameIdentifier":"267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makino, I"}],"nameIdentifiers":[{"nameIdentifier":"268","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"256.pdf","filesize":[{"value":"464.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"256.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/215/files/256.pdf"},"version_id":"c5cbded6-8b99-41d7-8672-0e220062cff1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"TNF-α induced RANTES chemokine expression via activation of NF-kB and p38 MAP kinase: roles of TNF-α in alcoholic liver diseases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TNF-α induced RANTES chemokine expression via activation of NF-kB and p38 MAP kinase: roles of TNF-α in alcoholic liver diseases","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-02-27"},"publish_date":"2007-02-27","publish_status":"0","recid":"215","relation_version_is_last":true,"title":["TNF-α induced RANTES chemokine expression via activation of NF-kB and p38 MAP kinase: roles of TNF-α in alcoholic liver diseases"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:36:10.759382+00:00"}