| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-02-27 |
| タイトル |
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|
タイトル |
Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
布村, 明彦
Chiba, S
Lippa, CF
Cras, P
Kalaria, RN
Takeda, A
Honda, K
Smith, MA
Perry, G
|
| 著者 ローマ字 |
|
|
|
Nunomura, Akihiko |
| 書誌情報 |
NEUROBIOLOGY OF DISEASE
巻 17,
号 1,
p. 108-113,
発行日 2004-10-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0969-9961 |
| DOI |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.nbd.2004.06.003 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.sciencedirect.com/science/journal/09699961 | http://www.sciencedirect.com/science/journal/09699961 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
An in situ approach was used to identify the oxidized RNA nucleoside, 8-hydroxyguanosine (8OHG) in the frontal cortex of familial Alzheimer disease (FAD) with a mutation in presenilin-1 (PS-1) or amyloid b protein precursor (AbPP) gene (n = 13, age 47-81 y). Neurons with marked 8OHG immunoreaction in the cytoplasm were widely distributed in the superior/middle frontal gyrus of FAD. Relative intensity measurements of neuronal 8OHG immunoreactivity showed that there was a significant increase in FAD compared with controls (n = 15, age 59-81 y), while there was no difference in relative 8OHG between the PS-1 and the AbPP FAD. Interestingly, a presymptomatic case carrying a PS-1 mutation showed a considerable level of relative 8OHG, and the increased levels of neuronal 8OHG in FAD were more prominent in cases with lower % area of Ab42 burden. These results suggest that oxidative stress is an early event involved in the pathological cascade of FAD. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
ACADEMIC PRESS, Nunomura, A; Chiba, S; Lippa, CF; Cras, P; Kalaria, RN; Takeda, A; Honda, K; Smith, MA; Perry, G, NEUROBIOLOGY OF DISEASE, 17(1), 108-113, 2004.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15350971 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1713 |
252.pdf (2.3 MB)
