{"created":"2023-06-19T11:20:11.788837+00:00","id":211,"links":{},"metadata":{"_buckets":{"deposit":"627442e0-957f-45e5-8e3f-153638fa682d"},"_deposit":{"created_by":3,"id":"211","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"211"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000211","sets":["7","7:24"]},"author_link":["243","244","245","246","247","248","249","250","251"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"113","bibliographicPageStart":"108","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"NEUROBIOLOGY OF DISEASE"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/09699961 | http://www.sciencedirect.com/science/journal/09699961","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"An in situ approach was used to identify the oxidized RNA nucleoside, 8-hydroxyguanosine (8OHG) in the frontal cortex of familial Alzheimer disease (FAD) with a mutation in presenilin-1 (PS-1) or amyloid b protein precursor (AbPP) gene (n = 13, age 47-81 y). Neurons with marked 8OHG immunoreaction in the cytoplasm were widely distributed in the superior/middle frontal gyrus of FAD. Relative intensity measurements of neuronal 8OHG immunoreactivity showed that there was a significant increase in FAD compared with controls (n = 15, age 59-81 y), while there was no difference in relative 8OHG between the PS-1 and the AbPP FAD. Interestingly, a presymptomatic case carrying a PS-1 mutation showed a considerable level of relative 8OHG, and the increased levels of neuronal 8OHG in FAD were more prominent in cases with lower % area of Ab42 burden. These results suggest that oxidative stress is an early event involved in the pathological cascade of FAD.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"ACADEMIC PRESS, Nunomura, A; Chiba, S; Lippa, CF; Cras, P; Kalaria, RN; Takeda, A; Honda, K; Smith, MA; Perry, G, NEUROBIOLOGY OF DISEASE, 17(1), 108-113, 2004.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.nbd.2004.06.003","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-9961","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"15350971"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2770"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1713"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Nunomura, Akihiko"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"布村, 明彦"},{"creatorName":"ヌノムラ, アキヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chiba, S"}],"nameIdentifiers":[{"nameIdentifier":"244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lippa, CF"}],"nameIdentifiers":[{"nameIdentifier":"245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Cras, P"}],"nameIdentifiers":[{"nameIdentifier":"246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kalaria, RN"}],"nameIdentifiers":[{"nameIdentifier":"247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeda, A"}],"nameIdentifiers":[{"nameIdentifier":"248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honda, K"}],"nameIdentifiers":[{"nameIdentifier":"249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Smith, MA"}],"nameIdentifiers":[{"nameIdentifier":"250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Perry, G"}],"nameIdentifiers":[{"nameIdentifier":"251","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"252.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"252.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/211/files/252.pdf"},"version_id":"99fb228c-da01-4f5f-bcf2-e94f6826c9df"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-02-27"},"publish_date":"2007-02-27","publish_status":"0","recid":"211","relation_version_is_last":true,"title":["Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:41:09.042491+00:00"}