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Hypoxia-independent overexpression of hypoxia-inducible factor 1α as an early change in mouse hepatocarcinogenesis.
https://asahikawa-med.repo.nii.ac.jp/records/1526
https://asahikawa-med.repo.nii.ac.jp/records/152656abb8a1-7d52-434e-941f-05849a8f54cd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2039.pdf (4.5 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||||||||||
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| 公開日 | 2009-04-24 | |||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||
| タイトル | Hypoxia-independent overexpression of hypoxia-inducible factor 1α as an early change in mouse hepatocarcinogenesis. | |||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| その他（別言語等）のタイトル | ||||||||||||||||||||||||||||
| その他のタイトル | Hypoxia-independent overexpression of HIF-1α as an early change in mouse hepatocarcinogenesis. | |||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||
| 著者 |
田中, 宏樹
× 田中, 宏樹
× Yamamoto, M
× Hashimoto, N
× Miyakoshi, M
× Tamakawa, S
× Yoshie, M
× Tokusashi, Y
× Yokoyama, K
× Yaginuma, Y
× Ogawa, K
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| 著者 ローマ字 | ||||||||||||||||||||||||||||
| Tanaka, Hiroki | ||||||||||||||||||||||||||||
| 著者 ローマ字 | ||||||||||||||||||||||||||||
| en | ||||||||||||||||||||||||||||
| 書誌情報 |
Cancer Research 巻 66, 号 23, p. 11263-11270, 発行日 2006-12-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 0008-5472 | |||||||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||||||
| 関連識別子 | 10.1158/0008-5472.CAN-06-1699 | |||||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||||
| 内容記述 | http://dx.doi.org/10.1158/0008-5472.CAN-06-1699 | http://dx.doi.org/10.1158/0008-5472.CAN-06-1699 | |||||||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||
| 内容記述 | HIF-1 is involved in tumor progression/metastasis and activated in various cancers. Here we show that HIF-1α, which plays a major role in HIF-1 activation, is over-expressed in preneoplastic hepatocytic lesions from a very early stage during hepatocarcinogenesis in mice and man. Transcriptional targets of HIF-1, such as VEGF, glut-1, c-met and Igf-2, were also over-expressed in mice lesions. HIF-1α expression was independent of hypoxia, because pimonidazole immunostaining was negative in the mouse lesions after treatment with pimonidazole. On the other hand, Akt, the pathway of which can up-regulate HIF-1α expression, was activated in the mouse lesions, while HIF-1α was markedly downregulated in the mouse HCC cell lines after treatment with a PI3 kinase (PI3K) inhibitor, LY294002, indicating that HIF-1α expression is dependent on PI3K/Akt signaling. Conversely, HIF-1α knockdown by siRNA in the HCC cell line resulted in decreased expression of activated Akt together with the HIF-1 target genes, indicating that Akt activation is reversely dependent on HIF-1 activation. Treating the HCC cells with Igf-2 upregulated both phospho-Akt and HIF-1α, while inhibition of Igf-2 by the neutralizing Igf-2 antibody downregulated them both, suggesting that Igf-2 may, at least in part, mediate the activation of Akt and HIF-1α. However, Akt was not activated by Igf-2 or EGF in the HIF-1α knockdown cells, indicating that expression of the HIF-1 target genesis necessary for the Akt activation. These findings suggest that the reciprocal activation of PI3K/Akt signaling and HIF-1α may be important in progression of hepatocarcinogenesis. | |||||||||||||||||||||||||||
| 注記 | ||||||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||||
| 資源タイプ | text | |||||||||||||||||||||||||||
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| 出版タイプ | AM | |||||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||||||||||
| ID(XooNIps) | ||||||||||||||||||||||||||||
| 17145871 | ||||||||||||||||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||||||||||||||||
| 1110 | ||||||||||||||||||||||||||||
