{"created":"2023-06-19T11:21:20.447679+00:00","id":1526,"links":{},"metadata":{"_buckets":{"deposit":"ac09ed7e-a616-4a5a-8ea5-daf9ef5955ff"},"_deposit":{"created_by":3,"id":"1526","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1526"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001526","sets":["7","7:24"]},"author_link":["4896","4897","4898","4899","4900","4901","4902","4903","4904","4905"],"item_5_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Hypoxia-independent overexpression of HIF-1α as an early change in mouse hepatocarcinogenesis.","subitem_alternative_title_language":"en"}]},"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicPageEnd":"11270","bibliographicPageStart":"11263","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Cancer Research"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1158/0008-5472.CAN-06-1699 | http://dx.doi.org/10.1158/0008-5472.CAN-06-1699","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HIF-1 is involved in tumor progression/metastasis and activated in various cancers. Here we show that HIF-1α, which plays a major role in HIF-1 activation, is over-expressed in preneoplastic hepatocytic lesions from a very early stage during hepatocarcinogenesis in mice and man. Transcriptional targets of HIF-1, such as VEGF, glut-1, c-met and Igf-2, were also over-expressed in mice lesions. HIF-1α expression was independent of hypoxia, because pimonidazole immunostaining was negative in the mouse lesions after treatment with pimonidazole. On the other hand, Akt, the pathway of which can up-regulate HIF-1α expression, was activated in the mouse lesions, while HIF-1α was markedly downregulated in the mouse HCC cell lines after treatment with a PI3 kinase (PI3K) inhibitor, LY294002, indicating that HIF-1α expression is dependent on PI3K/Akt signaling. Conversely, HIF-1α knockdown by siRNA in the HCC cell line resulted in decreased expression of activated Akt together with the HIF-1 target genes, indicating that Akt activation is reversely dependent on HIF-1 activation. Treating the HCC cells with Igf-2 upregulated both phospho-Akt and HIF-1α, while inhibition of Igf-2 by the neutralizing Igf-2 antibody downregulated them both, suggesting that Igf-2 may, at least in part, mediate the activation of Akt and HIF-1α. However, Akt was not activated by Igf-2 or EGF in the HIF-1α knockdown cells, indicating that expression of the HIF-1 target genesis necessary for the Akt activation. These findings suggest that the reciprocal activation of PI3K/Akt signaling and HIF-1α may be important in progression of hepatocarcinogenesis.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"author","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1158/0008-5472.CAN-06-1699","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0008-5472","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"17145871"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2433"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1110"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Tanaka, Hiroki"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 宏樹","creatorNameLang":"ja"},{"creatorName":"タナカ, ヒロキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4896","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, M","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, N"}],"nameIdentifiers":[{"nameIdentifier":"4898","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyakoshi, M","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4899","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamakawa, S"}],"nameIdentifiers":[{"nameIdentifier":"4900","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshie, M","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4901","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokusashi, Y","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4902","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoyama, K","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4903","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yaginuma, Y","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4904","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, K","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4905","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"2039.pdf","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2039.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1526/files/2039.pdf"},"version_id":"77574757-8e2d-435d-93f3-9ba1030117bc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypoxia-independent overexpression of hypoxia-inducible factor 1α as an early change in mouse hepatocarcinogenesis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypoxia-independent overexpression of hypoxia-inducible factor 1α as an early change in mouse hepatocarcinogenesis.","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-04-24"},"publish_date":"2009-04-24","publish_status":"0","recid":"1526","relation_version_is_last":true,"title":["Hypoxia-independent overexpression of hypoxia-inducible factor 1α as an early change in mouse hepatocarcinogenesis."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-25T07:53:09.529600+00:00"}