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Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease.
https://asahikawa-med.repo.nii.ac.jp/records/1513
https://asahikawa-med.repo.nii.ac.jp/records/1513dd5c6b10-ca32-4a73-8ead-bee525ebbf20
| 名前 / ファイル | ライセンス | アクション |
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2026.pdf (1.9 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||||||
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| 公開日 | 2009-04-24 | |||||||||||||||||||||||
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| タイトル | Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease. | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
滝山, 由美
× 滝山, 由美
× Miyokawa, N
× Tokusashi, Y
× Ito, K
× Kato, S
× Kimura, S
× Sato, K
× Katagiri, M
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| 著者 ローマ字 | ||||||||||||||||||||||||
| Takiyama, Yumi | ||||||||||||||||||||||||
| 著者 ローマ字 | ||||||||||||||||||||||||
| en | ||||||||||||||||||||||||
| 書誌情報 |
Thyroid 巻 12, 号 11, p. 935-943, 発行日 2002-11-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 1050-7256 | |||||||||||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.1089/105072502320908268 | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | http://www.liebertonline.com/loi/thy | http://www.liebertonline.com/loi/thy | |||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Interleukin(IL)‐l8 is a cloned cytokine that was identified originally as a factor having potent interferon(IFN)‐γ-inducing activity on Kupffer cells. First, we analyzed lL-18 gene expression by reverse transcription-polymerase chain reaction(RT-PCR) in rat thyroid FRTL-5 cells and human thyroid tissue samples. The expression of IL-18mRNA in FRTL-5 cells was enhanced by thryoid-stimulating hormone(TSH) in a dose-dependent manner. 8-Bromo-cyclic adenosine monophosphate(cAMP） also increased in lL-18 mRNA levels. Furthermore, TGCT clones that exhibited an increase in intracellular cAMP accumulation showed an increased IL-l8 mRNA signal when compared to controls. Taken together, these data suggested that the effect of TSH on IL-18 gene expression was mediated by activating protein kinase A. Treatment of FRTL-5 cells with the antithyroid drug, methimazole(MMI), suppressed this stimulatory action of TSH on IL-18 gene expression. Next, we examined IL-18 expression in human thyroid tissue derived from patients with autoimmune thyroid diseases(ATD). RTPCR and immunohistology demonstrated that human thyroid follicular cells expressed lL-18. Especially in thyroid tissue from a patient with Hashimoto's thyroiditis, expression was more diffuse and extensive, generally observed in close relation to a lymphocytic infiltrate. Also, IL-18 protein was distributed in the same follicles that express Fas-L and HLA-DR. This study is the first to demonstrate the detection of lL-l8 in the thyroid gland. The frequent expression of IL-l8 in thyrocytes suggests that IL-18 itself might be a secreted immunomodulator in ATD． | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 注記 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 注記 | Copyright 2002 Mary Ann Liebert, Inc. publisher | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 資源タイプ | text | |||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||||||
| ID(XooNIps) | ||||||||||||||||||||||||
| 12490070 | ||||||||||||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||||||||||||
| 796 | ||||||||||||||||||||||||
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滝山, 由美, Miyokawa, N, Tokusashi, Y, Ito, K, Kato, S, Kimura, S, Sato, K, Katagiri, M, n.d., Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease.: 935–943 p.
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