{"created":"2023-06-19T11:21:19.853936+00:00","id":1513,"links":{},"metadata":{"_buckets":{"deposit":"80ed757c-2ec8-485d-aff4-d89f5a272584"},"_deposit":{"created_by":3,"id":"1513","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1513"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001513","sets":["7","7:24"]},"author_link":["4801","4802","4803","4804","4805","4806","4807","4808"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"943","bibliographicPageStart":"935","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Thyroid"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.liebertonline.com/loi/thy | http://www.liebertonline.com/loi/thy","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interleukin(IL)‐l8 is a cloned cytokine that was identified originally as a factor having potent interferon(IFN)‐γ-inducing activity on Kupffer cells. First, we analyzed lL-18 gene expression by reverse transcription-polymerase chain reaction(RT-PCR) in rat thyroid FRTL-5 cells and human thyroid tissue samples. The expression of IL-18mRNA in FRTL-5 cells was enhanced by thryoid-stimulating hormone(TSH) in a dose-dependent manner. 8-Bromo-cyclic adenosine monophosphate(cAMP） also increased in lL-18 mRNA levels. Furthermore, TGCT clones that exhibited an increase in intracellular cAMP accumulation showed an increased IL-l8 mRNA signal when compared to controls. Taken together, these data suggested that the effect of TSH on IL-18 gene expression was mediated by activating protein kinase A. Treatment of FRTL-5 cells with the antithyroid drug, methimazole(MMI), suppressed this stimulatory action of TSH on IL-18 gene expression. Next, we examined IL-18 expression in human thyroid tissue derived from patients with autoimmune thyroid diseases(ATD). RTPCR and immunohistology demonstrated that human thyroid follicular cells expressed lL-18. Especially in thyroid tissue from a patient with Hashimoto's thyroiditis, expression was more diffuse and extensive, generally observed in close relation to a lymphocytic infiltrate. Also, IL-18 protein was distributed in the same follicles that express Fas-L and HLA-DR. This study is the first to demonstrate the detection of lL-l8 in the thyroid gland. The frequent expression of IL-l8 in thyrocytes suggests that IL-18 itself might be a secreted immunomodulator in ATD．","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Copyright 2002 Mary Ann Liebert, Inc. publisher","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1089/105072502320908268","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1050-7256","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"12490070"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1833"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"796"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Takiyama, Yumi"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"滝山, 由美","creatorNameLang":"ja"},{"creatorName":"タキヤマ, ユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyokawa, N","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokusashi, Y"}],"nameIdentifiers":[{"nameIdentifier":"4803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, K","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, S"}],"nameIdentifiers":[{"nameIdentifier":"4805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, S","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, K","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katagiri, M","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4808","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"2026.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2026.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1513/files/2026.pdf"},"version_id":"ed790f5f-60d0-4cdf-b359-5d3d5842d3e3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease.","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-04-24"},"publish_date":"2009-04-24","publish_status":"0","recid":"1513","relation_version_is_last":true,"title":["Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-25T07:52:39.789054+00:00"}