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Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice.

https://asahikawa-med.repo.nii.ac.jp/records/145
https://asahikawa-med.repo.nii.ac.jp/records/145
eeac8ed5-37cd-4119-a0d0-b70b64350156
名前 / ファイル ライセンス アクション
225.pdf 225.pdf (295.2 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2007-02-14
タイトル
タイトル Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice.
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 岡本, 聡

× 岡本, 聡

岡本, 聡

ja-Kana オカモト, サトシ

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Yokohama, S

× Yokohama, S

Yokohama, S

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Yoneda, M

× Yoneda, M

Yoneda, M

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Haneda, M

× Haneda, M

Haneda, M

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Nakamura, K

× Nakamura, K

Nakamura, K

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著者 ローマ字
Okamoto, Satoshi
出版社 ローマ字
ELSEVIER IRELAND LTD
書誌情報 HEPATOLOGY RESEARCH

巻 32, 号 1, p. 38-45, 発行日 2005-05-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1386-6346
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.hepres.2005.03.002
リンクURL
内容記述タイプ Other
内容記述 http://www.sciencedirect.com/science/journal/13866346 | http://www.sciencedirect.com/science/journal/13866346
抄録
内容記述タイプ Abstract
内容記述 Background/aims:The chemokines play roles in the development of immune mediated liver diseases. In this study, we investigate the involvement of macrophage inflammatory protein-1α (MIP-1α), one of the CC chemokines in concanavalin A (Con A)-induced liver injury in mice. Methods:Liver injury was induced by intravenous injection of Con A. Anti-mouse MIP-1α antibody, recombinant murine-MIP-1α and gadolinium chloride (GdCl_3) were administrated prior to Con A injection. Plasma alanine aminotransferase (ALT), MIP-1α, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) levels were determined and histological assessment of the liver was performed. Results:Plasma MIP-1α level was elevated after Con A injection. The elevated plasma ALT level, mortality rate and histological change after Con A injection were inhibited by anti-MIP-1α antibody pretreatment. The elevated plasma ALT level after Con A injection was further enhanced by recombinant murine-MIP-1α. The elevated plasma TNF-α and IFN-γ levels after Con A injection were inhibited by anti-MIP-1α antibody, and enhanced by recombinant murine-MIP-1α. GdCl_3 pretreatment inhibited the elevated plasma MIP-1α and ALT levels. Conclusions:These findings suggest that MIP-1α is produced from Kupffer cells after Con A injection, and this CC chemokine plays a crucial role in Con A-induced liver injury through induction of proinflammatory cytokines.
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資源タイプ text
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