| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-02-14 |
| タイトル |
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タイトル |
Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice. |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
岡本, 聡
Yokohama, S
Yoneda, M
Haneda, M
Nakamura, K
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| 著者 ローマ字 |
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Okamoto, Satoshi |
| 出版社 ローマ字 |
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ELSEVIER IRELAND LTD |
| 書誌情報 |
HEPATOLOGY RESEARCH
巻 32,
号 1,
p. 38-45,
発行日 2005-05-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1386-6346 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.hepres.2005.03.002 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/13866346 | http://www.sciencedirect.com/science/journal/13866346 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background/aims:The chemokines play roles in the development of immune mediated liver diseases. In this study, we investigate the involvement of macrophage inflammatory protein-1α (MIP-1α), one of the CC chemokines in concanavalin A (Con A)-induced liver injury in mice. Methods:Liver injury was induced by intravenous injection of Con A. Anti-mouse MIP-1α antibody, recombinant murine-MIP-1α and gadolinium chloride (GdCl_3) were administrated prior to Con A injection. Plasma alanine aminotransferase (ALT), MIP-1α, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) levels were determined and histological assessment of the liver was performed. Results:Plasma MIP-1α level was elevated after Con A injection. The elevated plasma ALT level, mortality rate and histological change after Con A injection were inhibited by anti-MIP-1α antibody pretreatment. The elevated plasma ALT level after Con A injection was further enhanced by recombinant murine-MIP-1α. The elevated plasma TNF-α and IFN-γ levels after Con A injection were inhibited by anti-MIP-1α antibody, and enhanced by recombinant murine-MIP-1α. GdCl_3 pretreatment inhibited the elevated plasma MIP-1α and ALT levels. Conclusions:These findings suggest that MIP-1α is produced from Kupffer cells after Con A injection, and this CC chemokine plays a crucial role in Con A-induced liver injury through induction of proinflammatory cytokines. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
author |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15876552 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1043 |
225.pdf (295.2 kB)
