WEKO3
-
RootNode
アイテム
Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice.
https://asahikawa-med.repo.nii.ac.jp/records/145
https://asahikawa-med.repo.nii.ac.jp/records/145eeac8ed5-37cd-4119-a0d0-b70b64350156
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
225.pdf (295.2 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2007-02-14 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
岡本, 聡
× 岡本, 聡
× Yokohama, S
× Yoneda, M
× Haneda, M
× Nakamura, K
|
|||||||||||||||||
| 著者 ローマ字 | ||||||||||||||||||
| Okamoto, Satoshi | ||||||||||||||||||
| 出版社 ローマ字 | ||||||||||||||||||
| ELSEVIER IRELAND LTD | ||||||||||||||||||
| 書誌情報 |
HEPATOLOGY RESEARCH 巻 32, 号 1, p. 38-45, 発行日 2005-05-01 |
|||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1386-6346 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1016/j.hepres.2005.03.002 | |||||||||||||||||
| リンクURL | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/13866346 | http://www.sciencedirect.com/science/journal/13866346 | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Background/aims:The chemokines play roles in the development of immune mediated liver diseases. In this study, we investigate the involvement of macrophage inflammatory protein-1α (MIP-1α), one of the CC chemokines in concanavalin A (Con A)-induced liver injury in mice. Methods:Liver injury was induced by intravenous injection of Con A. Anti-mouse MIP-1α antibody, recombinant murine-MIP-1α and gadolinium chloride (GdCl_3) were administrated prior to Con A injection. Plasma alanine aminotransferase (ALT), MIP-1α, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) levels were determined and histological assessment of the liver was performed. Results:Plasma MIP-1α level was elevated after Con A injection. The elevated plasma ALT level, mortality rate and histological change after Con A injection were inhibited by anti-MIP-1α antibody pretreatment. The elevated plasma ALT level after Con A injection was further enhanced by recombinant murine-MIP-1α. The elevated plasma TNF-α and IFN-γ levels after Con A injection were inhibited by anti-MIP-1α antibody, and enhanced by recombinant murine-MIP-1α. GdCl_3 pretreatment inhibited the elevated plasma MIP-1α and ALT levels. Conclusions:These findings suggest that MIP-1α is produced from Kupffer cells after Con A injection, and this CC chemokine plays a crucial role in Con A-induced liver injury through induction of proinflammatory cytokines. | |||||||||||||||||
| 注記 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 注記 | author | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 資源タイプ | text | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| フォーマット | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||
| ID(XooNIps) | ||||||||||||||||||
| 15876552 | ||||||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||||||
| 1043 | ||||||||||||||||||
Share
Cite as
岡本, 聡, Yokohama, S, Yoneda, M, Haneda, M, Nakamura, K, n.d., Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice.: 38–45 p.
Loading...
