{"created":"2023-06-19T11:20:08.301545+00:00","id":145,"links":{},"metadata":{"_buckets":{"deposit":"4351415d-92de-4556-9eec-5a4066c454bb"},"_deposit":{"created_by":3,"id":"145","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"145"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000145","sets":["7","7:24"]},"author_link":["104","105","106","107","108"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"45","bibliographicPageStart":"38","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"HEPATOLOGY RESEARCH"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/13866346 | http://www.sciencedirect.com/science/journal/13866346","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/aims:The chemokines play roles in the development of immune mediated liver diseases. In this study, we investigate the involvement of macrophage inflammatory protein-1α (MIP-1α), one of the CC chemokines in concanavalin A (Con A)-induced liver injury in mice. Methods:Liver injury was induced by intravenous injection of Con A. Anti-mouse MIP-1α antibody, recombinant murine-MIP-1α and gadolinium chloride (GdCl_3) were administrated prior to Con A injection. Plasma alanine aminotransferase (ALT), MIP-1α, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) levels were determined and histological assessment of the liver was performed. Results:Plasma MIP-1α level was elevated after Con A injection. The elevated plasma ALT level, mortality rate and histological change after Con A injection were inhibited by anti-MIP-1α antibody pretreatment. The elevated plasma ALT level after Con A injection was further enhanced by recombinant murine-MIP-1α. The elevated plasma TNF-α and IFN-γ levels after Con A injection were inhibited by anti-MIP-1α antibody, and enhanced by recombinant murine-MIP-1α. GdCl_3 pretreatment inhibited the elevated plasma MIP-1α and ALT levels. Conclusions:These findings suggest that MIP-1α is produced from Kupffer cells after Con A injection, and this CC chemokine plays a crucial role in Con A-induced liver injury through induction of proinflammatory cytokines.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.hepres.2005.03.002","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1386-6346","subitem_source_identifier_type":"ISSN"}]},"item_5_text_16":{"attribute_name":"出版社 ローマ字","attribute_value_mlt":[{"subitem_text_value":"ELSEVIER IRELAND LTD"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"15876552"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2400"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1043"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Okamoto, Satoshi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡本, 聡"},{"creatorName":"オカモト, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokohama, S"}],"nameIdentifiers":[{"nameIdentifier":"105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoneda, M"}],"nameIdentifiers":[{"nameIdentifier":"106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haneda, M"}],"nameIdentifiers":[{"nameIdentifier":"107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, K"}],"nameIdentifiers":[{"nameIdentifier":"108","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"225.pdf","filesize":[{"value":"295.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"225.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/145/files/225.pdf"},"version_id":"b4ed28f1-90c8-4aee-adae-68f1038e26b5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice.","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-02-14"},"publish_date":"2007-02-14","publish_status":"0","recid":"145","relation_version_is_last":true,"title":["Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:49:38.712328+00:00"}