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Inhibitors of the Ca^<2+>/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N)

https://asahikawa-med.repo.nii.ac.jp/records/1446
https://asahikawa-med.repo.nii.ac.jp/records/1446
f7f59879-8ce5-4924-8bb8-1937d492b323
名前 / ファイル ライセンス アクション
1903.pdf 1903.pdf (352.3 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2009-03-31
タイトル
タイトル Inhibitors of the Ca^<2+>/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N)
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 石田, 敦彦

× 石田, 敦彦

石田, 敦彦

ja-Kana イシダ, アツヒコ

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Sueyoshi, N

× Sueyoshi, N

Sueyoshi, N

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Takao, T

× Takao, T

Takao, T

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Nimura, T

× Nimura, T

Nimura, T

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Sugiyama, Y

× Sugiyama, Y

Sugiyama, Y

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Numano, T

× Numano, T

Numano, T

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Shigeri, Y

× Shigeri, Y

Shigeri, Y

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Taniguchi, T

× Taniguchi, T

Taniguchi, T

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Kameshita, I

× Kameshita, I

Kameshita, I

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著者 ローマ字
Ishida, Atsuhiko
書誌情報 Biochemical and Biophysical Research Communications

巻 363, 号 3, p. 715-721, 発行日 2007-11-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0006-291X
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.bbrc.2007.09.022
リンクURL
内容記述タイプ Other
内容記述 http://dx.doi.org/10.1016/j.bbrc.2007.09.022 | http://dx.doi.org/10.1016/j.bbrc.2007.09.022
抄録
内容記述タイプ Abstract
内容記述 Ca^<2+>/calmodulin-dependent protein kinase phosphatase (CaMKP) and its nuclear isoform CaMKP-N are unique Ser/Thr protein phosphatases that negatively regulate the Ca^<2+>/calmodulin-dependent protein kinase (CaMK) cascade by dephosphorylating multifunctional CaMKI, II, and IV. However, the lack of specific inhibitors of these phosphatases has hampered studies on these enzymes in vivo. In an attempt to obtain specific inhibitors, we searched inhibitory compounds and found that Evans Blue and Chicago Sky Blue 6B served as effective inhibitors for CaMKP. These compounds also inhibited CaMKP-N, but inhibited neither protein phosphatase 2C, another member of PPM family phosphatase, nor calcineurin, a typical PPP family phosphatase. The minimum structure required for the inhibition was 1-amino-8-naphthol-4-sulfonic acid. When Neuro2a cells cotransfected with CaMKIV and CaMKP-N were treated with these compounds, the dephosphorylation of CaMKIV was strongly suppressed, suggesting that these compounds could be used as potent inhibitors of CaMKP and CaMKP-N in vivo as well as in vitro.
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内容記述タイプ Other
資源タイプ text
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出版タイプ AM
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内容記述 application/pdf
ID(XooNIps)
17897624
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1784
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Cite as

石田, 敦彦, Sueyoshi, N, Takao, T, Nimura, T, Sugiyama, Y, Numano, T, Shigeri, Y, Taniguchi, T, Kameshita, I, n.d., Inhibitors of the Ca^&lt;2+&gt;/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N): 715–721 p.

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