{"created":"2023-06-19T11:21:16.472683+00:00","id":1446,"links":{},"metadata":{"_buckets":{"deposit":"826b8fca-88be-42ab-bb45-5dbac06b4c8b"},"_deposit":{"created_by":3,"id":"1446","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1446"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001446","sets":["7","7:24"]},"author_link":["4651","4652","4653","4654","4655","4656","4657","4658","4659"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"721","bibliographicPageStart":"715","bibliographicVolumeNumber":"363","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1016/j.bbrc.2007.09.022 | http://dx.doi.org/10.1016/j.bbrc.2007.09.022","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ca^<2+>/calmodulin-dependent protein kinase phosphatase (CaMKP) and its nuclear isoform CaMKP-N are unique Ser/Thr protein phosphatases that negatively regulate the Ca^<2+>/calmodulin-dependent protein kinase (CaMK) cascade by dephosphorylating multifunctional CaMKI, II, and IV. However, the lack of specific inhibitors of these phosphatases has hampered studies on these enzymes in vivo. In an attempt to obtain specific inhibitors, we searched inhibitory compounds and found that Evans Blue and Chicago Sky Blue 6B served as effective inhibitors for CaMKP. These compounds also inhibited CaMKP-N, but inhibited neither protein phosphatase 2C, another member of PPM family phosphatase, nor calcineurin, a typical PPP family phosphatase. The minimum structure required for the inhibition was 1-amino-8-naphthol-4-sulfonic acid. When Neuro2a cells cotransfected with CaMKIV and CaMKP-N were treated with these compounds, the dephosphorylation of CaMKIV was strongly suppressed, suggesting that these compounds could be used as potent inhibitors of CaMKP and CaMKP-N in vivo as well as in vitro.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2007.09.022","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"17897624"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2182"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1784"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Ishida, Atsuhiko"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石田, 敦彦"},{"creatorName":"イシダ, アツヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sueyoshi, N"}],"nameIdentifiers":[{"nameIdentifier":"4652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takao, T"}],"nameIdentifiers":[{"nameIdentifier":"4653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nimura, T"}],"nameIdentifiers":[{"nameIdentifier":"4654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiyama, Y"}],"nameIdentifiers":[{"nameIdentifier":"4655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Numano, T"}],"nameIdentifiers":[{"nameIdentifier":"4656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeri, Y"}],"nameIdentifiers":[{"nameIdentifier":"4657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniguchi, T"}],"nameIdentifiers":[{"nameIdentifier":"4658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kameshita, I"}],"nameIdentifiers":[{"nameIdentifier":"4659","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"1903.pdf","filesize":[{"value":"352.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1903.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1446/files/1903.pdf"},"version_id":"38a28697-218f-4675-b928-cc14167602f5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibitors of the Ca^<2+>/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitors of the Ca^<2+>/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N)","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-31"},"publish_date":"2009-03-31","publish_status":"0","recid":"1446","relation_version_is_last":true,"title":["Inhibitors of the Ca^<2+>/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:20:14.870253+00:00"}