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Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa
https://asahikawa-med.repo.nii.ac.jp/records/142
https://asahikawa-med.repo.nii.ac.jp/records/142efc71d48-296b-44cc-a693-486373a0175b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
221.pdf (315.5 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||
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| 公開日 | 2007-02-14 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
上口, 勇次郎
× 上口, 勇次郎
× Tateno, H
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| 著者 ローマ字 | ||||||||||||
| Kamiguchi, Yujiro | ||||||||||||
| 出版社 ローマ字 | ||||||||||||
| ELSEVIER SCIENCE BV | ||||||||||||
| 書誌情報 |
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 巻 504, 号 1-2, p. 183-191, 発行日 2002-07-01 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0027-5107 | |||||||||||
| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1016/S0027-5107(02)00091-X | |||||||||||
| リンクURL | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/00275107 | http://www.sciencedirect.com/science/journal/00275107 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Previous studies on the clastogenic effects of mutagens on human sperm chromosomes were reviewed. A marked increase of structural chromosome aberrations (SCAs) has been reported in the spermatozoa irradiated in vitro with five kinds of ionizing radiation (^137Cs γ-, ^60Co γ-, X-, and ^3H β-rays and ^252Cf neutrons). The micronucleus (MN) test with hybrid two-cell embryos generated from human sperm and hamster oocytes was shown to be useful as a simple and rapid method for assessing the effects of radiation. Radiosensitivity of human spermatozoa was highest, being followed by golden hamster, Chinese hamster and mouse spermatozoa. Chromosome-damaging effects were also found with some chemicals (bleomycin, daunomycin, methyl methanesulfonate, triethylenemelamine, neocarzinostatin, N-methyl-N′-nitro-N-nitorosoguanidine and mitomycin C (MMC)), but not with other chemicals (urethane, nitrobenzene, dioxin, cyclophosphamide (CP), benzo(a)pyrene (BP) and N-nitrosodimethylamine (NDMA)). The clastogenicity of chemical metabolites was confirmed for CP and BP, by using the S9-based metabolic activation system. The results of sperm chromosome analysis from cancer patients who had undergone radio- and/or chemotherapy were contradictory among investigators and further studies are necessary. The importance of mutagenicity testing with human spermatozoa is discussed. | |||||||||||
| 注記 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 注記 | author | |||||||||||
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| 内容記述タイプ | Other | |||||||||||
| 資源タイプ | text | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| ID(XooNIps) | ||||||||||||
| 12106658 | ||||||||||||
| 閲覧数(XooNIps) | ||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||
| 699 | ||||||||||||
