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Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa
https://asahikawa-med.repo.nii.ac.jp/records/142
https://asahikawa-med.repo.nii.ac.jp/records/142efc71d48-296b-44cc-a693-486373a0175b
名前 / ファイル | ライセンス | アクション |
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221.pdf (315.5 kB)
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2007-02-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
上口, 勇次郎
× 上口, 勇次郎× Tateno, H |
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著者 ローマ字 | ||||||
Kamiguchi, Yujiro | ||||||
出版社 ローマ字 | ||||||
ELSEVIER SCIENCE BV | ||||||
書誌情報 |
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 巻 504, 号 1-2, p. 183-191, 発行日 2002-07-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-5107 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/S0027-5107(02)00091-X | |||||
リンクURL | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://www.sciencedirect.com/science/journal/00275107 | http://www.sciencedirect.com/science/journal/00275107 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Previous studies on the clastogenic effects of mutagens on human sperm chromosomes were reviewed. A marked increase of structural chromosome aberrations (SCAs) has been reported in the spermatozoa irradiated in vitro with five kinds of ionizing radiation (^137Cs γ-, ^60Co γ-, X-, and ^3H β-rays and ^252Cf neutrons). The micronucleus (MN) test with hybrid two-cell embryos generated from human sperm and hamster oocytes was shown to be useful as a simple and rapid method for assessing the effects of radiation. Radiosensitivity of human spermatozoa was highest, being followed by golden hamster, Chinese hamster and mouse spermatozoa. Chromosome-damaging effects were also found with some chemicals (bleomycin, daunomycin, methyl methanesulfonate, triethylenemelamine, neocarzinostatin, N-methyl-N′-nitro-N-nitorosoguanidine and mitomycin C (MMC)), but not with other chemicals (urethane, nitrobenzene, dioxin, cyclophosphamide (CP), benzo(a)pyrene (BP) and N-nitrosodimethylamine (NDMA)). The clastogenicity of chemical metabolites was confirmed for CP and BP, by using the S9-based metabolic activation system. The results of sperm chromosome analysis from cancer patients who had undergone radio- and/or chemotherapy were contradictory among investigators and further studies are necessary. The importance of mutagenicity testing with human spermatozoa is discussed. | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
注記 | author | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
資源タイプ | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
12106658 | ||||||
閲覧数(XooNIps) | ||||||
2530 | ||||||
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699 |