{"created":"2023-06-19T11:20:08.164374+00:00","id":142,"links":{},"metadata":{"_buckets":{"deposit":"be889e63-0eea-4258-8a24-6a9f7a3c225d"},"_deposit":{"created_by":3,"id":"142","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"142"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000142","sets":["7","7:24"]},"author_link":["85","86"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"191","bibliographicPageStart":"183","bibliographicVolumeNumber":"504","bibliographic_titles":[{"bibliographic_title":"MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/00275107 | http://www.sciencedirect.com/science/journal/00275107","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Previous studies on the clastogenic effects of mutagens on human sperm chromosomes were reviewed. A marked increase of structural chromosome aberrations (SCAs) has been reported in the spermatozoa irradiated in vitro with five kinds of ionizing radiation (^137Cs γ-, ^60Co γ-, X-, and ^3H β-rays and ^252Cf neutrons). The micronucleus (MN) test with hybrid two-cell embryos generated from human sperm and hamster oocytes was shown to be useful as a simple and rapid method for assessing the effects of radiation. Radiosensitivity of human spermatozoa was highest, being followed by golden hamster, Chinese hamster and mouse spermatozoa. Chromosome-damaging effects were also found with some chemicals (bleomycin, daunomycin, methyl methanesulfonate, triethylenemelamine, neocarzinostatin, N-methyl-N′-nitro-N-nitorosoguanidine and mitomycin C (MMC)), but not with other chemicals (urethane, nitrobenzene, dioxin, cyclophosphamide (CP), benzo(a)pyrene (BP) and N-nitrosodimethylamine (NDMA)). The clastogenicity of chemical metabolites was confirmed for CP and BP, by using the S9-based metabolic activation system. The results of sperm chromosome analysis from cancer patients who had undergone radio- and/or chemotherapy were contradictory among investigators and further studies are necessary. The importance of mutagenicity testing with human spermatozoa is discussed.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0027-5107(02)00091-X","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0027-5107","subitem_source_identifier_type":"ISSN"}]},"item_5_text_16":{"attribute_name":"出版社 ローマ字","attribute_value_mlt":[{"subitem_text_value":"ELSEVIER SCIENCE BV"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"12106658"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2530"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"699"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kamiguchi, Yujiro"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上口, 勇次郎"},{"creatorName":"カミグチ, ユウジロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"85","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tateno, H"}],"nameIdentifiers":[{"nameIdentifier":"86","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"221.pdf","filesize":[{"value":"315.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"221.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/142/files/221.pdf"},"version_id":"27c4f309-8aeb-45ed-8176-87bfd3a368f1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-02-14"},"publish_date":"2007-02-14","publish_status":"0","recid":"142","relation_version_is_last":true,"title":["Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:25:10.876841+00:00"}