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Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice
https://asahikawa-med.repo.nii.ac.jp/records/1356
https://asahikawa-med.repo.nii.ac.jp/records/1356a4efef73-1ee5-4c01-bc45-d4bbf49fe393
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||
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公開日 | 2009-03-11 | |||||||||||||||||
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タイトル | Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice | |||||||||||||||||
言語 | en | |||||||||||||||||
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言語 | eng | |||||||||||||||||
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資源タイプ | journal article | |||||||||||||||||
著者 |
河野, 透
× 河野, 透
× Ohmiya, Y
× Yuzurihara, M
× Suzuki, Y
× Kase, Y
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著者 ローマ字 | ||||||||||||||||||
Kohno, Toru | ||||||||||||||||||
書誌情報 |
European Journal of Pharmacology 巻 592, 号 1-3, p. 62-66, 発行日 2008-09-01 |
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収録物識別子タイプ | ISSN | |||||||||||||||||
収録物識別子 | 0014-2999 | |||||||||||||||||
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関連タイプ | isVersionOf | |||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||
関連識別子 | 10.1016/j.ejphar.2008.06.087 | |||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||
内容記述 | http://dx.doi.org/10.1016/j.ejphar.2008.06.087 | http://dx.doi.org/10.1016/j.ejphar.2008.06.087 | |||||||||||||||||
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内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | The present studies investigated behavioral and neurochemical aspects of the noradrenergic and serotonergic nervous systems in streptozotocin-induced diabetic mice. We previously reported that intrathecal (I.t.) injection of norepinephrine significantly potentiated antinociception in diabetic mice compared to that in non-diabetic mice, and that antinociception due to norepinephrine injection was completely abolished by pretreatment with yohimbine, an α_2-adrenoceptor antagonist. The present studies demonstrated that I.t. injection of clonidine also showed more potent antinociceptive activity in diabetic mice than in non-diabetic mice, but that I.t. methoxamine injection did not affect diabetic or non-diabetic mice. The antinociceptive potency due to I.t. injection of 5-HT was significantly lower in diabetic than in non-diabetic mice. In a neurochemical study, we found that the density of [^3H]-rauwolscine binding sites in spinal α_2-adrenoceptors was significantly higher in diabetic than in non-diabetic mice, but that the binding affinity was unchanged. Spinal norepinephrine turnover was determined by measuring the decline in tissue norepinephrine concentration at 3 h after injection of the tyrosine hydroxylase inhibitor α-methyl-p-tyrosine. The spinal norepinephrine concentration decreased to 43.7% from the baseline in non-diabetic mice, while it was 21.0% in diabetic mice. These results suggest that, based on the decrease of norepinephrine release in the spinal cord, up-regulation of spinal α_2-adrenoceptors caused the increase of antinociception due to I.t. injection of an α_2-adrenoceptor agonist in streptozotocin-induced diabetic mice, and it seemed that the stimulation of α_2-adrenoceptors potentiated the antinociceptive effect. Thus, the spinal noradrenergic systems play an important moderating role in diabetes-induced neuropathic pain. | |||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||
注記 | author | |||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||
資源タイプ | text | |||||||||||||||||
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出版タイプ | AM | |||||||||||||||||
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内容記述タイプ | Other | |||||||||||||||||
内容記述 | application/pdf | |||||||||||||||||
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18625215 | ||||||||||||||||||
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2533 |
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Cite as
河野, 透, Ohmiya, Y, Yuzurihara, M, Suzuki, Y, Kase, Y, n.d., Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice: 62–66 p.
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