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Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice

https://asahikawa-med.repo.nii.ac.jp/records/1356
https://asahikawa-med.repo.nii.ac.jp/records/1356
a4efef73-1ee5-4c01-bc45-d4bbf49fe393
名前 / ファイル ライセンス アクション
1628.pdf 1628.pdf (320.4 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2009-03-11
タイトル
タイトル Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 河野, 透

× 河野, 透

河野, 透

ja-Kana コウノ, トオル

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Ohmiya, Y

× Ohmiya, Y

Ohmiya, Y

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Yuzurihara, M

× Yuzurihara, M

Yuzurihara, M

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Suzuki, Y

× Suzuki, Y

Suzuki, Y

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Kase, Y

× Kase, Y

Kase, Y

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著者 ローマ字
Kohno, Toru
書誌情報 European Journal of Pharmacology

巻 592, 号 1-3, p. 62-66, 発行日 2008-09-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0014-2999
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.ejphar.2008.06.087
リンクURL
内容記述タイプ Other
内容記述 http://dx.doi.org/10.1016/j.ejphar.2008.06.087 | http://dx.doi.org/10.1016/j.ejphar.2008.06.087
抄録
内容記述タイプ Abstract
内容記述 The present studies investigated behavioral and neurochemical aspects of the noradrenergic and serotonergic nervous systems in streptozotocin-induced diabetic mice. We previously reported that intrathecal (I.t.) injection of norepinephrine significantly potentiated antinociception in diabetic mice compared to that in non-diabetic mice, and that antinociception due to norepinephrine injection was completely abolished by pretreatment with yohimbine, an α_2-adrenoceptor antagonist. The present studies demonstrated that I.t. injection of clonidine also showed more potent antinociceptive activity in diabetic mice than in non-diabetic mice, but that I.t. methoxamine injection did not affect diabetic or non-diabetic mice. The antinociceptive potency due to I.t. injection of 5-HT was significantly lower in diabetic than in non-diabetic mice. In a neurochemical study, we found that the density of [^3H]-rauwolscine binding sites in spinal α_2-adrenoceptors was significantly higher in diabetic than in non-diabetic mice, but that the binding affinity was unchanged. Spinal norepinephrine turnover was determined by measuring the decline in tissue norepinephrine concentration at 3 h after injection of the tyrosine hydroxylase inhibitor α-methyl-p-tyrosine. The spinal norepinephrine concentration decreased to 43.7% from the baseline in non-diabetic mice, while it was 21.0% in diabetic mice. These results suggest that, based on the decrease of norepinephrine release in the spinal cord, up-regulation of spinal α_2-adrenoceptors caused the increase of antinociception due to I.t. injection of an α_2-adrenoceptor agonist in streptozotocin-induced diabetic mice, and it seemed that the stimulation of α_2-adrenoceptors potentiated the antinociceptive effect. Thus, the spinal noradrenergic systems play an important moderating role in diabetes-induced neuropathic pain.
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資源タイプ text
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Cite as

河野, 透, Ohmiya, Y, Yuzurihara, M, Suzuki, Y, Kase, Y, n.d., Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice: 62–66 p.

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