| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-03-11 |
| タイトル |
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タイトル |
Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
河野, 透
Ohmiya, Y
Yuzurihara, M
Suzuki, Y
Kase, Y
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| 著者 ローマ字 |
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|
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Kohno, Toru |
| 書誌情報 |
European Journal of Pharmacology
巻 592,
号 1-3,
p. 62-66,
発行日 2008-09-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0014-2999 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.ejphar.2008.06.087 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1016/j.ejphar.2008.06.087 | http://dx.doi.org/10.1016/j.ejphar.2008.06.087 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The present studies investigated behavioral and neurochemical aspects of the noradrenergic and serotonergic nervous systems in streptozotocin-induced diabetic mice. We previously reported that intrathecal (I.t.) injection of norepinephrine significantly potentiated antinociception in diabetic mice compared to that in non-diabetic mice, and that antinociception due to norepinephrine injection was completely abolished by pretreatment with yohimbine, an α_2-adrenoceptor antagonist. The present studies demonstrated that I.t. injection of clonidine also showed more potent antinociceptive activity in diabetic mice than in non-diabetic mice, but that I.t. methoxamine injection did not affect diabetic or non-diabetic mice. The antinociceptive potency due to I.t. injection of 5-HT was significantly lower in diabetic than in non-diabetic mice. In a neurochemical study, we found that the density of [^3H]-rauwolscine binding sites in spinal α_2-adrenoceptors was significantly higher in diabetic than in non-diabetic mice, but that the binding affinity was unchanged. Spinal norepinephrine turnover was determined by measuring the decline in tissue norepinephrine concentration at 3 h after injection of the tyrosine hydroxylase inhibitor α-methyl-p-tyrosine. The spinal norepinephrine concentration decreased to 43.7% from the baseline in non-diabetic mice, while it was 21.0% in diabetic mice. These results suggest that, based on the decrease of norepinephrine release in the spinal cord, up-regulation of spinal α_2-adrenoceptors caused the increase of antinociception due to I.t. injection of an α_2-adrenoceptor agonist in streptozotocin-induced diabetic mice, and it seemed that the stimulation of α_2-adrenoceptors potentiated the antinociceptive effect. Thus, the spinal noradrenergic systems play an important moderating role in diabetes-induced neuropathic pain. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
author |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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18625215 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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2533 |
1628.pdf (320.4 kB)
