{"created":"2023-06-19T11:21:12.143352+00:00","id":1356,"links":{},"metadata":{"_buckets":{"deposit":"d9831a61-cce4-49c5-bff6-dfe2f8d198cf"},"_deposit":{"created_by":3,"id":"1356","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1356"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001356","sets":["6:29:30","7","7:24"]},"author_link":["4420","4421","4422","4423","4424"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"66","bibliographicPageStart":"62","bibliographicVolumeNumber":"592","bibliographic_titles":[{"bibliographic_title":"European Journal of Pharmacology"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1016/j.ejphar.2008.06.087 | http://dx.doi.org/10.1016/j.ejphar.2008.06.087","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present studies investigated behavioral and neurochemical aspects of the noradrenergic and serotonergic nervous systems in streptozotocin-induced diabetic mice. We previously reported that intrathecal (I.t.) injection of norepinephrine significantly potentiated antinociception in diabetic mice compared to that in non-diabetic mice, and that antinociception due to norepinephrine injection was completely abolished by pretreatment with yohimbine, an α_2-adrenoceptor antagonist.  The present studies demonstrated that I.t. injection of clonidine also showed more potent antinociceptive activity in diabetic mice than in non-diabetic mice, but that I.t. methoxamine injection did not affect diabetic or non-diabetic mice.  The antinociceptive potency due to I.t. injection of 5-HT was significantly lower in diabetic than in non-diabetic mice. In a neurochemical study, we found that the density of [^3H]-rauwolscine binding sites in spinal α_2-adrenoceptors was significantly higher in diabetic than in non-diabetic mice, but that the binding affinity was unchanged.  Spinal norepinephrine turnover was determined by measuring the decline in tissue norepinephrine concentration at 3 h after injection of the tyrosine hydroxylase inhibitor α-methyl-p-tyrosine. The spinal norepinephrine concentration decreased to 43.7% from the baseline in non-diabetic mice, while it was 21.0% in diabetic mice. These results suggest that, based on the decrease of norepinephrine release in the spinal cord, up-regulation of spinal α_2-adrenoceptors caused the increase of antinociception due to I.t. injection of an α_2-adrenoceptor agonist in streptozotocin-induced diabetic mice, and it seemed that the stimulation of α_2-adrenoceptors potentiated the antinociceptive effect.  Thus, the spinal noradrenergic systems play an important moderating role in diabetes-induced neuropathic pain.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ejphar.2008.06.087","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-2999","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"18625215"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2123"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2533"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kohno, Toru"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 透"},{"creatorName":"コウノ, トオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohmiya, Y"}],"nameIdentifiers":[{"nameIdentifier":"4421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuzurihara, M"}],"nameIdentifiers":[{"nameIdentifier":"4422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Y"}],"nameIdentifiers":[{"nameIdentifier":"4423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kase, Y"}],"nameIdentifiers":[{"nameIdentifier":"4424","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"1628.pdf","filesize":[{"value":"320.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1628.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1356/files/1628.pdf"},"version_id":"d08b3f0d-36a4-4d52-906f-53ecaa0d3f91"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","24","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-11"},"publish_date":"2009-03-11","publish_status":"0","recid":"1356","relation_version_is_last":true,"title":["Role of α_2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:21:11.397121+00:00"}