| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-03-11 |
| タイトル |
|
|
タイトル |
Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
吉田, 成孝
Terayama, R
Bando, Y
Murakami, K
Kato, K
Kishibe, M
|
| 著者 ローマ字 |
|
|
|
Yoshida, Shigetaka |
| 書誌情報 |
Neuroscience
巻 148,
号 1,
p. 175-187,
発行日 2007-08-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0306-4522 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.neuroscience.2007.05.037 |
| リンクURL |
|
|
内容記述タイプ |
Other |
|
内容記述 |
http://dx.doi.org/10.1016/j.neuroscience.2007.05.037 | http://dx.doi.org/10.1016/j.neuroscience.2007.05.037 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Previous studies indicated that the expression of neuropsin, a serine protease, is induced in mature oligodendrocytes after injury to the central nervous system (CNS). The pathophysiology of spinal cord injury (SCI) involves primary and secondary mechanisms, the latter contributing further to permanent losses of function. To explore the role of neuropsin after SCI, histochemical and behavioral analyses were performed in wild-type (WT) and neuropsin-deficient (neuropsin^<-/->) mice using a crush injury model, a well-characterized and consistently reproducible model of SCI. In situ hybridization revealed that neuropsin mRNA expression was induced in the spinal cord white matter from WT mice after crush SCI, peaking at day 4. Neuropsin^<-/-> mice showed attenuated demyelination, oligodendrocyte death, and axonal damage after SCI. Although axonal degeneration in the corticospinal tract was obvious caudal to the lesion site in both strains of mice after SCI, the number of surviving nerve fibers caudal to the lesion was significantly larger in neuropsin^<-/-> mice than WT mice. Behavioral analysis revealed that the recovery at days 10-42 was significantly improved in neuropsin^<-/-> mice compared to WT mice in spite of the severe initial hindlimb impairments due to SCI in both strains. These observations suggest that neuropsin is involved in the secondary phase of the pathogenesis of SCI mediated by demyelination, oligodendrocyte death, and axonal degeneration. |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
author |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
17629414 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
1778 |
1609.pdf (3.2 MB)
