{"created":"2023-06-19T11:21:11.643616+00:00","id":1345,"links":{},"metadata":{"_buckets":{"deposit":"7a3e7f16-9089-48f6-8262-b684524fda56"},"_deposit":{"created_by":3,"id":"1345","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1345"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001345","sets":["6:29:30","7","7:24"]},"author_link":["4359","4360","4361","4362","4363","4364"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"187","bibliographicPageStart":"175","bibliographicVolumeNumber":"148","bibliographic_titles":[{"bibliographic_title":"Neuroscience"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1016/j.neuroscience.2007.05.037 | http://dx.doi.org/10.1016/j.neuroscience.2007.05.037","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Previous studies indicated that the expression of neuropsin, a serine protease, is induced in mature oligodendrocytes after injury to the central nervous system (CNS).  The pathophysiology of spinal cord injury (SCI) involves primary and secondary mechanisms, the latter contributing further to permanent losses of function.  To explore the role of neuropsin after SCI, histochemical and behavioral analyses were performed in wild-type (WT) and neuropsin-deficient (neuropsin^<-/->) mice using a crush injury model, a well-characterized and consistently reproducible model of SCI.  In situ hybridization revealed that neuropsin mRNA expression was induced in the spinal cord white matter from WT mice after crush SCI, peaking at day 4.  Neuropsin^<-/-> mice showed attenuated demyelination, oligodendrocyte death, and axonal damage after SCI.  Although axonal degeneration in the corticospinal tract was obvious caudal to the lesion site in both strains of mice after SCI, the number of surviving nerve fibers caudal to the lesion was significantly larger in neuropsin^<-/-> mice than WT mice.  Behavioral analysis revealed that the recovery at days 10-42 was significantly improved in neuropsin^<-/-> mice compared to WT mice in spite of the severe initial hindlimb impairments due to SCI in both strains.  These observations suggest that neuropsin is involved in the secondary phase of the pathogenesis of SCI mediated by demyelination, oligodendrocyte death, and axonal degeneration.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neuroscience.2007.05.037","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0306-4522","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"17629414"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1778"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Yoshida, Shigetaka"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 成孝"},{"creatorName":"ヨシダ, シゲタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terayama, R"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bando, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kishibe, M"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"1609.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1609.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1345/files/1609.pdf"},"version_id":"6156482d-87d4-4bbf-80e1-6993ef8cdd36"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","24","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-11"},"publish_date":"2009-03-11","publish_status":"0","recid":"1345","relation_version_is_last":true,"title":["Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:33:25.565846+00:00"}