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Immunolocalization of a Novel Collectin CL-K1 in Murine Tissues

https://asahikawa-med.repo.nii.ac.jp/records/1344
https://asahikawa-med.repo.nii.ac.jp/records/1344
4b1ac893-0a1a-4e5b-b889-c7391300bcdb
名前 / ファイル ライセンス アクション
1608.pdf 1608.pdf (2.2 MB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2009-03-11
タイトル
タイトル Immunolocalization of a Novel Collectin CL-K1 in Murine Tissues
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 若宮, 伸隆

× 若宮, 伸隆

若宮, 伸隆

ja-Kana ワカミヤ, ノブタカ

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Motomura, W

× Motomura, W

Motomura, W

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Yoshizaki, T

× Yoshizaki, T

Yoshizaki, T

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Ohtani, K

× Ohtani, K

Ohtani, K

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Okumura, T

× Okumura, T

Okumura, T

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Fukuda, M

× Fukuda, M

Fukuda, M

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Fukuzawa, J

× Fukuzawa, J

Fukuzawa, J

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Mori, K

× Mori, K

Mori, K

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Jang, SJ

× Jang, SJ

Jang, SJ

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Nomura, N

× Nomura, N

Nomura, N

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Yoshida, I

× Yoshida, I

Yoshida, I

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Suzuki, Y

× Suzuki, Y

Suzuki, Y

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Kohgo, Y

× Kohgo, Y

Kohgo, Y

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Wakamiya, N

× Wakamiya, N

Wakamiya, N

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著者 ローマ字
Wakamiya, Nobutaka
書誌情報 Journal of Histochemistry and Cytochemistry

巻 56, 号 3, p. 243-252, 発行日 2008-03-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0022-1554
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1369/jhc.7A7312.2007
リンクURL
内容記述タイプ Other
内容記述 http://dx.doi.org/10.1369/jhc.7A7312.2007 | http://dx.doi.org/10.1369/jhc.7A7312.2007
抄録
内容記述タイプ Abstract
内容記述 We have recently identified a novel collectin, CL-K1, that may play a role in innate immunity as a member of the collectin family. In this study using mice, we investigated the tissue distribution of CL-K1 for better understanding of its pathophysiological relevance. Real-time PCR analyses demonstrated that CL-K1 mRNA was expressed in all tissues tested. Immunohistochemical analyses demonstrated that CL-K1 was expressed in proximal tubules of kidney, in mucosa of the gastrointestinal tract, and in bronchial glands of bronchioles similar to the localization of SP-A and SP-D in these pulmonary structures. Immunohistochemistry also showed that CL-K1 was highly expressed in hepatocytes around the central veins in liver, which suggests that murine CL-K1 might be mainly produced in theliver and secreted into the blood stream as is human CL-K1. CL-K1 was especially detected in vascular smooth muscle in several types of tissue. In addition, it was also expressed in intestinal Paneth cells, in mesangial cells of kidney, in pancreatic islet D cells, and in neurons of the brain. It is of interest that this profile of CL-K1 expression is unique among the collectins. Taken together, these histological findings may be useful for the understanding biological function of this novel collectin.
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内容記述タイプ Other
資源タイプ text
著者版フラグ
出版タイプ AM
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内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
18040075
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ダウンロード数(XooNIps)
1398
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Cite as

若宮, 伸隆, Motomura, W, Yoshizaki, T, Ohtani, K, Okumura, T, Fukuda, M, Fukuzawa, J, Mori, K, Jang, SJ, Nomura, N, Yoshida, I, Suzuki, Y, Kohgo, Y, Wakamiya, N, n.d., Immunolocalization of a Novel Collectin CL-K1 in Murine Tissues: 243–252 p.

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