| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-03-11 |
| タイトル |
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|
タイトル |
Immunolocalization of a Novel Collectin CL-K1 in Murine Tissues |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
若宮, 伸隆
Motomura, W
Yoshizaki, T
Ohtani, K
Okumura, T
Fukuda, M
Fukuzawa, J
Mori, K
Jang, SJ
Nomura, N
Yoshida, I
Suzuki, Y
Kohgo, Y
Wakamiya, N
|
| 著者 ローマ字 |
|
|
|
Wakamiya, Nobutaka |
| 書誌情報 |
Journal of Histochemistry and Cytochemistry
巻 56,
号 3,
p. 243-252,
発行日 2008-03-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-1554 |
| DOI |
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|
関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1369/jhc.7A7312.2007 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://dx.doi.org/10.1369/jhc.7A7312.2007 | http://dx.doi.org/10.1369/jhc.7A7312.2007 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We have recently identified a novel collectin, CL-K1, that may play a role in innate immunity as a member of the collectin family. In this study using mice, we investigated the tissue distribution of CL-K1 for better understanding of its pathophysiological relevance. Real-time PCR analyses demonstrated that CL-K1 mRNA was expressed in all tissues tested. Immunohistochemical analyses demonstrated that CL-K1 was expressed in proximal tubules of kidney, in mucosa of the gastrointestinal tract, and in bronchial glands of bronchioles similar to the localization of SP-A and SP-D in these pulmonary structures. Immunohistochemistry also showed that CL-K1 was highly expressed in hepatocytes around the central veins in liver, which suggests that murine CL-K1 might be mainly produced in theliver and secreted into the blood stream as is human CL-K1. CL-K1 was especially detected in vascular smooth muscle in several types of tissue. In addition, it was also expressed in intestinal Paneth cells, in mesangial cells of kidney, in pancreatic islet D cells, and in neurons of the brain. It is of interest that this profile of CL-K1 expression is unique among the collectins. Taken together, these histological findings may be useful for the understanding biological function of this novel collectin. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
author |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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18040075 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1398 |
1608.pdf (2.2 MB)
