| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2009-03-11 |
| タイトル |
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タイトル |
A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
高橋, 伸彦
Nagamine, M
Tanno, S
Motomura, W
Kohgo, Y
Okumura, T
|
| 著者 ローマ字 |
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Takahashi, Nobuhiko |
| 書誌情報 |
Biochemical and Biophysical Research Communications
巻 360,
号 1,
p. 244-250,
発行日 2007-08-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006-291X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.bbrc.2007.06.040 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://dx.doi.org/10.1016/j.bbrc.2007.06.040 | http://dx.doi.org/10.1016/j.bbrc.2007.06.040 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Diacylglycerol kinase (DGK) is one of lipid-regulating enzymes, catalyzes phosphorylation of diacylglycerol to phosphatidic acid. Because skeletal muscle, a major insulin-target organ for glucose disposal, expresses DGK, we investigated in the present study a role of DGK on glucose transport in skeletal muscle cells. PCR study showed that C2C12 myotubes expressed DGKα, δ, ε, ζ, or θ isoform mRNA. R59022, a specific inhibitor of DGK, significantly increased glucose transport, p38 and MKK3/6 activation in C2C12 myotubes. The R59022-induced glucose transport was blocked by SB203580, a specific p38 inhibitor. In contrast, R59022 failed to stimulate both possible known mechanisms to enhance glucose transport, an IRS1-PI3K-Akt pathway, muscle contraction signaling or GLUT1 and 4 expression. All these results suggest that DGK may play a role in glucose transport in the skeletal muscle cells through modulating a MKK3/6-p38 signaling pathway. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
author |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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17588539 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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2378 |
1595.pdf (256.0 kB)
