{"created":"2023-06-19T11:21:10.551922+00:00","id":1324,"links":{},"metadata":{"_buckets":{"deposit":"76b2968d-3e29-4ff6-9e34-7c79f867a764"},"_deposit":{"created_by":3,"id":"1324","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1324"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001324","sets":["6:29:30","7","7:24"]},"author_link":["4227","4228","4229","4230","4231","4232"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"250","bibliographicPageStart":"244","bibliographicVolumeNumber":"360","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1016/j.bbrc.2007.06.040 | http://dx.doi.org/10.1016/j.bbrc.2007.06.040","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Diacylglycerol kinase (DGK) is one of lipid-regulating enzymes, catalyzes phosphorylation of diacylglycerol to phosphatidic acid.  Because skeletal muscle, a major insulin-target organ for glucose disposal, expresses DGK, we investigated in the present study a role of DGK on glucose transport in skeletal muscle cells.  PCR study showed that C2C12 myotubes expressed DGKα, δ, ε, ζ, or θ isoform mRNA.  R59022, a specific inhibitor of DGK, significantly increased glucose transport, p38 and MKK3/6 activation in C2C12 myotubes.  The R59022-induced glucose transport was blocked by SB203580, a specific p38 inhibitor.  In contrast, R59022 failed to stimulate both possible known mechanisms to enhance glucose transport, an IRS1-PI3K-Akt pathway, muscle contraction signaling or GLUT1 and 4 expression.  All these results suggest that DGK may play a role in glucose transport in the skeletal muscle cells through modulating a MKK3/6-p38 signaling pathway.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"author","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2007.06.040","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"17588539"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"4223"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2378"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Takahashi, Nobuhiko"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 伸彦"},{"creatorName":"タカハシ, ノブヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4227","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagamine, M"}],"nameIdentifiers":[{"nameIdentifier":"4228","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanno, S"}],"nameIdentifiers":[{"nameIdentifier":"4229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Motomura, W"}],"nameIdentifiers":[{"nameIdentifier":"4230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohgo, Y"}],"nameIdentifiers":[{"nameIdentifier":"4231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumura, T"}],"nameIdentifiers":[{"nameIdentifier":"4232","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"1595.pdf","filesize":[{"value":"256.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1595.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1324/files/1595.pdf"},"version_id":"539290f6-f50e-490e-a0ea-33ae63a799c8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","24","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-11"},"publish_date":"2009-03-11","publish_status":"0","recid":"1324","relation_version_is_last":true,"title":["A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:20:04.695560+00:00"}