| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-07-18 |
| タイトル |
|
|
タイトル |
核医学におけるモデル解析の基礎 |
|
言語 |
ja |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
秀毛, 範至
高塩, 哲也
佐藤, 順一
石川, 幸雄
油野, 民雄
|
| 著者 ローマ字 |
|
|
|
Shuke, Noriyuki |
| 著者 ローマ字 |
|
|
|
en |
|
|
Takashio, Tatsuya |
| 著者 ローマ字 |
|
|
|
en |
|
|
Sato, Junichi |
| 著者 ローマ字 |
|
|
|
en |
|
|
Ishikawa, Yukio |
| 著者 ローマ字 |
|
|
|
en |
|
|
Aburano, Tamio |
| 著者 ローマ字 |
|
|
|
en |
| 書誌情報 |
メディカルレビュー
巻 19,
号 2,
p. 13-22,
発行日 1995-05-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0285-1067 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In nuclear medicine imaging, an organ's blood flow or particular function is assessed by visualizing the in vivo distribution of radioactive tracers. Various pathological states lead to spatial or temporal changes in the distribution of these tracers. Since the presence and degree of such pathological changes are usually evaluated visually, image interpretation may be biased to some extent by the interpreter's subjective criteria. In order to make image interpretation more objective, a quantitative approach based on modeling of tracer kinetics has been applied to many nuclear medicine studies, utilizing numerical data derived from digital images. In this brief report, the basic concepts and procedures for kinetic modeling analysis are introduced. As an example of compartment model analysis, classical 2-compartment model analysis using plasma data for two renal blood flow agents (Tc-99m-MAG3 and l-131-OIH) is performed to compare the distribution and elimination kinetics of these tracers. To better understand the tissue distribution of blood flow tracers, the basic concept of blood flow and tissue clearance is introduced based on a tissue blood flow model. In addition, graphical analysis and its application to Tc-99m-HMPAO are discussed as a simple method for determining tissue clearance. These kinetic analyses are quite simple, but the application of this method to various tracers could result in the identification of quantitative parameters that are clinically useful in the field of nuclear medicine. |
|
言語 |
en |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
著者版 |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
1996004352 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
1671 |
1100.pdf (3.8 MB)
