ログイン
言語:

WEKO3

  • トップ
  • ランキング
To

Field does not validate

To

Field does not validate

To
lat lon distance


インデックスリンク

インデックスツリー

  • RootNode

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. Public
  1. Public
  2. 国外雑誌論文

Expression of cutaneous lymphocyte-associated antigen (CLA) in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris (PPP)

https://asahikawa-med.repo.nii.ac.jp/records/735
https://asahikawa-med.repo.nii.ac.jp/records/735
fd5a741e-7a76-49a9-a3ee-34f6dae0e7b4
名前 / ファイル ライセンス アクション
915.pdf 915.pdf (1.5 MB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2008-03-28
タイトル
タイトル Expression of cutaneous lymphocyte-associated antigen (CLA) in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris (PPP)
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 原渕, 保明

× 原渕, 保明

原渕, 保明

ja-Kana ハラブチ, ヤスアキ

Search repository
Nozawa, H

× Nozawa, H

Nozawa, H

Search repository
Kishibe, K

× Kishibe, K

Kishibe, K

Search repository
Takahara, M

× Takahara, M

Takahara, M

Search repository
著者 ローマ字
Harabuchi, Yasuaki
書誌情報 Clinical Immunology

巻 116, 号 1, p. 42-53, 発行日 2005-07-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1521-6616
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.clim.2005.01.009
リンクURL
内容記述タイプ Other
内容記述 http://www.sciencedirect.com/science/journal/15216616 | http://www.sciencedirect.com/science/journal/15216616
抄録
内容記述タイプ Abstract
内容記述 Pustulosis palmaris et plantaris (PPP) is known to be a one of the tonsil-related diseases because tonsillectomy is quite effective in curing this condition. However etiological association between tonsils and PPP have not fully clarified yet. Cutaneous lymphocyte-associated antigen (CLA) is known to be a specific homing receptor that facilitates T-cell migration into skin. In this study, we investigated the expression of CLA on T-cells in tonsil, peripheral blood, and skin from patients with PPP. Two-color flow cytometric and two-color immunohistological analyses revealed that the numbers of CLA/CD3 double-positive cells in freshly isolated tonsillar mononuclear cells (TMC) and in tonsillar tissues were significantly higher in patients with PPP than in patients without PPP (P < 0.01, each). In vitro stimulus with α-streptococcal antigens enhanced CLA expression of tonsillar T-cells and TGF-β production of TMC in patients with PPP (P < 0.01, each), but did not in patients without PPP. In peripheral blood from PPP patients, the number of the CLA/CD3 double-positive cells significantly decreased at 6 months after tonsillectomy (P < 0.05). The CLA/CD3 double-positive cells and the postcapillary venule that expressed with a ligand of CLA, E-selectin, were found more frequently in the plantar skin from patients with PPP as compared to that from healthy volunteers (P < 0.01, each). These data suggest that a novel immune response to α-streptococci may enhance CLA expression on tonsillar T-cells through TGF-β production in patients with PPP, resulting in moving of CLA-positive tonsillar T-cells to skin and tissue damages. This may play a key role in pathogenesis of PPP.
注記
内容記述タイプ Other
注記 Academic Press, Nozawa, Hayabusa ; Kishibe, Kan ; Takahara, Miki ; Harabuchi, Yasuaki, Clinical Immunology, 116(1), 2005, 42-53.
\nauthor
資源タイプ
内容記述タイプ Other
資源タイプ text
著者版フラグ
出版タイプ AM
フォーマット
内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
15925831
閲覧数(XooNIps)
ダウンロード数(XooNIps)
928
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-19 13:54:44.881937
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3