ログイン
言語:

WEKO3

  • トップ
  • ランキング
To

Field does not validate

To

Field does not validate

To
lat lon distance


インデックスリンク

インデックスツリー

  • RootNode

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. Public
  1. Public
  2. 国外雑誌論文

Familial hyperinsulinemia due to a structurally abnormal insulin: Definition of an emerging new clinical syndrome.

https://asahikawa-med.repo.nii.ac.jp/records/723
https://asahikawa-med.repo.nii.ac.jp/records/723
1a1cac36-27bc-42ec-9bbb-f1424768cd47
名前 / ファイル ライセンス アクション
903.pdf 903.pdf (3.9 MB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2008-03-28
タイトル
タイトル Familial hyperinsulinemia due to a structurally abnormal insulin: Definition of an emerging new clinical syndrome.
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 羽田, 勝計

× 羽田, 勝計

羽田, 勝計

ja-Kana ハネダ, マサカズ

Search repository
Polonsky, KS

× Polonsky, KS

Polonsky, KS

Search repository
Bergenstal, RM

× Bergenstal, RM

Bergenstal, RM

Search repository
Jaspan, JB

× Jaspan, JB

Jaspan, JB

Search repository
Shoelson, SE

× Shoelson, SE

Shoelson, SE

Search repository
Blix, PM

× Blix, PM

Blix, PM

Search repository
Chan, SJ

× Chan, SJ

Chan, SJ

Search repository
Kwok, SCM

× Kwok, SCM

Kwok, SCM

Search repository
Wishner, WB

× Wishner, WB

Wishner, WB

Search repository
Zeider, A

× Zeider, A

Zeider, A

Search repository
Olefsky, JM

× Olefsky, JM

Olefsky, JM

Search repository
Freidenberg, G

× Freidenberg, G

Freidenberg, G

Search repository
Tager, HS

× Tager, HS

Tager, HS

Search repository
Steiner, DF

× Steiner, DF

Steiner, DF

Search repository
Rubenstein, AH

× Rubenstein, AH

Rubenstein, AH

Search repository
著者 ローマ字
Haneda, Masakazu
書誌情報 New England Journal of Medicine

巻 310, 号 20, p. 1288-1294, 発行日 1984-01-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0028-4793
リンクURL
内容記述タイプ Other
内容記述 http://www.ncbi.nlm.nih.gov/pubmed?term=Familial%20hyperinsulinemia%20due%20to%20a%20structurally%20abnormal%20insulin%3A%20Definition%20of%20an%20emerging%20new%20clinical%20syndrome. | http://www.ncbi.nlm.nih.gov/pubmed?term=Familial%20hyperinsulinemia%20due%20to%20a%20structurally%20abnormal%20insulin%3A%20Definition%20of%20an%20emerging%20new%20clinical%20syndrome.
抄録
内容記述タイプ Abstract
内容記述 We have identified a patient with mild diabetes, marked fasting hyperinsulinemia (89 to 130 microU of insulin per milliliter), and a reduced fasting C-peptide: insulin molar ratio of 1.11 to 1.50 (normal, greater than 4). The patient responded normally to exogenous insulin. However, her endogenous immunoreactive insulin showed reduced biologic activity during a glucose-clamp study with hyperglycemia and a reduced ability to bind to the insulin receptor and stimulate glucose transport in vitro. Family studies showed that five additional relatives in three generations had variable degrees of glucose intolerance, marked hyperinsulinemia, and a reduced peripheral C-peptide:insulin molar ratio. Restriction-endonuclease cleavage of DNA isolated from circulating leukocytes in the patient and in family members with hyperinsulinemia revealed loss of the MboII recognition site in one allele of the insulin gene--consistent with a point mutation at position 24 or 25 in the insulin B chain. Other studies using high-pressure liquid chromatography and detailed gene analysis have identified the defect as a serine for phenylalanine substitution at position 24 of the insulin B chain. The secretion of a structurally abnormal insulin should be considered in patients with hyperinsulinemia who respond normally to exogenous insulin and have a reduced C-peptide:insulin molar ratio. Glucose tolerance may range from relatively normal to overtly diabetic.
注記
内容記述タイプ Other
注記 Massachusetts Medical Society, Haneda, M. ; Polonsky, KS. ; Bergenstal, RM. ; Jaspan, JB ; Shoelson, SE, ; Blix, PM ; Chan, SJ ; Kwok, SCM ; Wishner, WB ; Zeidler; A. ; Olefsky, JM ; Freidenberg, G,: Tager, HS. ; Steiner, DF : Rubenstein, AH, New England Journal of Medicine, 310(20), 1984, 1288-1294.
\npublisher
資源タイプ
内容記述タイプ Other
資源タイプ text
フォーマット
内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
6371526
閲覧数(XooNIps)
ダウンロード数(XooNIps)
2063
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-19 13:55:05.469874
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

羽田, 勝計, Polonsky, KS, Bergenstal, RM, Jaspan, JB, Shoelson, SE, Blix, PM, Chan, SJ, Kwok, SCM, Wishner, WB, Zeider, A, Olefsky, JM, Freidenberg, G, Tager, HS, Steiner, DF, Rubenstein, AH, n.d., Familial hyperinsulinemia due to a structurally abnormal insulin: Definition of an emerging new clinical syndrome.: 1288–1294 p.

Loading...

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3