| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-03-28 |
| タイトル |
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タイトル |
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
高橋, 悟
Saito, T
Hisanaga, S
Pant, HC
Kulkarni, AB
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| 著者 ローマ字 |
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Takahashi, Satoru |
| 書誌情報 |
Journal of Biological Chemistry
巻 278,
号 12,
p. 10506-10515,
発行日 2003-03-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0021-9258 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1074/jbc.M211964200 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed?term=Tau%20phosphorylation%20by%20cyclin-dependent%20kinase%205%2Fp39%20during%20brain%20development%20reduces%20its%20affinity%20for%20microtubules | http://www.ncbi.nlm.nih.gov/pubmed?term=Tau%20phosphorylation%20by%20cyclin-dependent%20kinase%205%2Fp39%20during%20brain%20development%20reduces%20its%20affinity%20for%20microtubules |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The microtubule-associated protein tau is a developmentally regulated neuronal phosphoprotein. The phosphorylation of tau reduces its ability to bind and stabilize axonal microtubules during axonal growth. Although tau is phosphorylated by cyclin-dependent kinase 5 (Cdk5) in vitro, its in vivo roles remain unclear. Here, we show that tau is phosphorylated by Cdk5/p39 during brain development, resulting in a reduction of its affinity for microtubules. The activity of Cdk5 is tightly regulated by association with its neuronal activators, p35 or p39. The p35 and p39 expression levels were investigated in the developing mouse brain: the p39 expression level was higher in embryonic hindbrain and spinal cord, and in postnatal cerebral cortex, while that of p35 was most prominent in cerebral cortex at earlier stages of development. The ability of Cdk5 to phosphorylate tau was higher when in association with p39 than in association with p35. Tau phosphorylation at Ser-202 and Thr-205 was decreased in Cdk5-/- mouse brain but not in p35-/- mouse brain, suggesting that Cdk5/p39 is responsible for the in vivo phosphorylation of tau at these sites. Our data suggest that tau phosphorylation by Cdk5 may provide the neuronal microtubules with dynamic properties in a region-specific and developmentally regulated manner. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
American Society for Biochemistry and Molecular Biology, Satoru, Takahashi ; Taro, Saito ; Shin-ichi, Hisanaga ; Harish C. Pant ; Ashok B. Kulkarni, Journal of Biological Chemistry, 278(12), 2003, 10506-10515
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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12536148 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1220 |
902.pdf (5.8 MB)
