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Expression of neuropsin in oligodendrocytes after injury to the CNS
https://asahikawa-med.repo.nii.ac.jp/records/715
https://asahikawa-med.repo.nii.ac.jp/records/715b3bd25da-5d0c-42f5-853b-e7e11880de5b
| 名前 / ファイル | ライセンス | アクション |
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895.pdf (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2008-03-28 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Expression of neuropsin in oligodendrocytes after injury to the CNS | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
吉田, 成孝
× 吉田, 成孝
× He, XP
× Shiosaka, S
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| 著者 ローマ字 | ||||||||||||||
| Yoshida, Shigetaka | ||||||||||||||
| 書誌情報 |
Neuroscience Research 巻 39, 号 4, p. 455-462, 発行日 2001-01-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0168-0102 | |||||||||||||
| DOI | ||||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1016/S0168-0102(01)00200-0 | |||||||||||||
| リンクURL | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/01680102 | http://www.sciencedirect.com/science/journal/01680102 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Proteases are involved in a variety of processes including demyelination after injury to the central nervous systyem. Neuropsin is a serine protease, which is constitutively expressed in the neurons of the limbic system. In the present study, intrahippocampal kainate injection and enucleation were performed on adult mice. Neuropsin mRNA and protein expression was detected by in situ hybridization and immunohistochemistry. Double in situ hybridization confirmed that the mRNA expression was induced in oligodendrocytes. One day after kainate injection to the hippocampus, neuropsin mRNA was expressed, peaking 4–8 days postoperatively and disappearing at 14 days. Immunohistochemistry and immunoelectron microscopy revealed that neuropsin was expressed in the cell body of oligodendrocytes and myelin. To see if neuropsin degrades myelin protein, purified myelin was incubated with recombinant neuropsin. A decrease in the intensity of the bands of myelin basic protein was observed. These results indicate that neuropsin is involved in demyelination. | |||||||||||||
| 注記 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 注記 | Elsevier, Xiao-Ping He, Sadao Shiosaka and Shigetaka Yoshida, Neuroscience Research, 39(4), 2001, 455-462. \nauthor |
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| 資源タイプ | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 11274744 | ||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||
| 1220 | ||||||||||||||
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Cite as
吉田, 成孝, He, XP, Shiosaka, S, n.d., Expression of neuropsin in oligodendrocytes after injury to the CNS: 455–462 p.
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