| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2008-02-05 |
| タイトル |
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タイトル |
Protein phosphatases that regulate multifunctional Ca2+/calmodulin-dependent protein kinases: from biochemistry to pharmacology |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
石田, 敦彦
Shigeri, Y
Taniguchi, T
Kameshita, I
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| 著者 ローマ字 |
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Ishida, Atsuhiko |
| 書誌情報 |
Pharmacology and Therapeutics
巻 100,
号 3,
p. 291-305,
発行日 2003-12-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0163-7258 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.pharmthera.2003.09.003 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/01637258 | http://www.sciencedirect.com/science/journal/01637258 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Multifunctional Ca(2+)/calmodulin-dependent protein kinases (CaMKs) play pivotal roles in Ca(2+) signaling pathways, such as the regulation of the neuronal functions of learning, memory, and neuronal cell death. The activities of the kinases are strictly regulated by protein phosphorylation/dephosphorylation. Although the activation mechanisms for multifunctional CaMKs through phosphorylation, which correspond to "switch on," have been extensively studied, the negative regulatory mechanisms through dephosphorylation, which correspond to "switch off," have not. In this review, we focused on the regulation of multifunctional CaMKs by the protein phosphatases responsible. We first summarized the current understanding of negative regulation of CaMKs by known protein phosphatases and their physiological significance. We then discussed newly developed methods for detection of protein phosphatases involved in the regulation of CaMKs. We also summarized the biochemical properties of a novel protein phosphatase, which we isolated with the new methods and designated as CaMK phosphatase (CaMKP), and its homologue. Pharmacological implications for neuronal functions including memory and neuronal cell death are discussed from the viewpoint that regulation of protein kinase activity can be elucidated by focusing on protein phosphatases involved in its "switch off" mechanism. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Pergamon Press, Ishida, Atsuhiko ; Shigeri, Yasushi ; Taniguchi, Takanobu ; Kameshita, Isamu, Pharmacology and Therapeutics, 100(3), 2003, 291-305.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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14652114 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1303 |
855.pdf (469.9 kB)
