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A cytogenetic study of in-vitro matured murine oocytes after ICSI by human sperm
https://asahikawa-med.repo.nii.ac.jp/records/639
https://asahikawa-med.repo.nii.ac.jp/records/6390318fc96-8b39-4aee-8030-c6c718e52e13
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
800.pdf (183.6 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||
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| 公開日 | 2007-12-03 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | A cytogenetic study of in-vitro matured murine oocytes after ICSI by human sperm | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
千石, 一雄
× 千石, 一雄
× Tsuchiya, K
× Kamiguchi, Y
× Ishikawa, M
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| 著者 ローマ字 | ||||||||||||||||
| Sengoku, Kazuo | ||||||||||||||||
| 書誌情報 |
Human Reproduction 巻 17, 号 2, p. 420-425, 発行日 2002-02-01 |
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| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 0268-1161 | |||||||||||||||
| DOI | ||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1093/humrep/17.2.420 | |||||||||||||||
| リンクURL | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | http://humrep.oxfordjournals.org/cgi/reprint/17/2/420 | http://humrep.oxfordjournals.org/cgi/reprint/17/2/420 | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | BACKGROUND: The purpose of this study was to investigate the chromosomal complement and developmental potential of in-vitro matured murine oocytes following ICSI by human sperm. METHODS: Heterologous ICSI fertilization between mouse oocytes and human sperm was employed in order to overcome the reduced fertilization rates observed after conventional IVF due to zona hardening during in-vitro maturation, and to assess separately maternal and paternal chromosome complements. Cytogenetic analyses were performed in four types of oocytes: (I) in-vitro matured metaphase II (MII) oocytes; (ii) in-vivo matured MII oocytes; (iii) in-vitro matured oocytes after ICSI; (iv) in-vivo matured oocytes after ICSI. RESULTS: Activation rates after ICSI of in-vitro matured oocytes was lower than that of in-vivo matured oocytes (69.9 versus 97.2%, P < 0.01), and premature chromosomal condensation was only observed in in-vitro matured oocytes. However, there were no significant differences in developmental rates after successful activation between in-vivo and in-vitro matured ICSI oocytes (69.7 versus 76.6%). The incidences of aneuploidy and structural aberrations were similar between the ICSI embryos and non-ICSI (MII) oocytes. Furthermore, the frequency of chromosomal aberrations was not associated with in-vitro or in-vivo maturation. Similar analyses of paternal chromosomes indicated that there were no significant differences in the incidence of chromosomal aberrations between the embryos derived from in-vitro and in-vivo matured oocytes. CONCLUSIONS: These results suggest that in-vitro matured oocytes following ICSI do not lead to an increase in the frequency of aneuploidy and structural aberrations when human sperm are injected into mouse oocytes. | |||||||||||||||
| 注記 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 注記 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Reproduction following peer review. The definitive publisher-authenticated version Oxford University Press, Human Reproduction, 17(2), 2002, 420-425 is available online at: http://humrep.oxfordjournals.org/cgi/content/abstract/17/2/420. \nauthor |
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| 資源タイプ | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 資源タイプ | text | |||||||||||||||
| フォーマット | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||
| ID(XooNIps) | ||||||||||||||||
| 11821288 | ||||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||||
| 1003 | ||||||||||||||||
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Cite as
千石, 一雄, Tsuchiya, K, Kamiguchi, Y, Ishikawa, M, n.d., A cytogenetic study of in-vitro matured murine oocytes after ICSI by human sperm: 420–425 p.
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