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T-cell repertoire in the tonsils of patients with IgA nephropathy

https://asahikawa-med.repo.nii.ac.jp/records/635
https://asahikawa-med.repo.nii.ac.jp/records/635
098e456d-1b17-4317-8b74-86e96ef06dea
名前 / ファイル ライセンス アクション
796.pdf 796.pdf (173.5 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2007-12-03
タイトル
タイトル T-cell repertoire in the tonsils of patients with IgA nephropathy
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 高原, 幹

× 高原, 幹

高原, 幹

ja-Kana タカハラ, ミキ

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Kishibe, K

× Kishibe, K

Kishibe, K

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Nozawa, H

× Nozawa, H

Nozawa, H

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Harabuchi, Y

× Harabuchi, Y

Harabuchi, Y

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著者 ローマ字
Takahara, Miki
書誌情報 Acta Oto-Laryngologica Supplement

号 555, p. 25-27, 発行日 2004-12-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0001-6489
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1080/03655230410003341
リンクURL
内容記述タイプ Other
内容記述 http://www.ncbi.nlm.nih.gov/pubmed | http://www.ncbi.nlm.nih.gov/pubmed
抄録
内容記述タイプ Abstract
内容記述 It is known that IgA nephropathy (IgAN) often progresses to end-stage renal failure within a period of 20 years. There are many reports suggesting the relationship between the tonsillar autoimmune response and the pathogenesis of IgA nephropathy, however, definitive evidence has not been detected. Recently, studies of T-cell receptor variable (TCR V) region gene usage in human autoimmune disease showed that the TCR V beta repertoire of pathogenic T cells was highly restricted. In this study, we examined expression of TCR V beta families in tonsils from IgAN patients. The study group consisted of 7 IgAN patients and 7 obstructive sleep apnea syndrome (OSAS) patients. Total RNA was extracted from the tonsils of each patients, and expression of each TCR V beta subfamily gene were examined by reverse transcription-polymerase chain reaction (RT-PCR) method. V beta 6 is more frequently used in tonsils of IgAN patients than in those of OSAS patients (p = 0.01), and V beta 20 is more frequently used in OSAS patients than IgAN patients (p =0.01). It was already reported that the frequency of V beta 6 subfamily usage is elevated in both peripheral blood lymphocytes (PBL) and renal tissues of IgAN patients Therefore, our results suggested that the tonsils may be one of the sources of specific T cells related to the pathogenesis of IgAN.
注記
内容記述タイプ Other
注記 Taylor & Francis, Takahara, Miki ; Kishibe, Kan ; Nozawa, Hayabusa ; Harabuchi, Yasuaki, Acta Oto-Laryngologica Supplement, 555, 2004, 25-27.
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資源タイプ text
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出版タイプ AM
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内容記述 application/pdf
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高原, 幹, Kishibe, K, Nozawa, H, Harabuchi, Y, n.d., T-cell repertoire in the tonsils of patients with IgA nephropathy: 25–27 p.

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