| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-12-03 |
| タイトル |
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タイトル |
LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
山本, 明美
Deraison, C
Bonnart, C
Bitoun, E
Robinson, R
O'Brien, TJ
Wakamatsu, K
Ohtsubo, S
Takahashi, H
Hashimoto, Y
Dopping-Hepenstal, PJ
McGrath, JA
Iizuka, H
Richard, G
Hovnanian, A
Patricia, J C D-H
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| 著者 ローマ字 |
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Yamamoto, Akemi |
| 書誌情報 |
Journal of Investigative Dermatology
巻 124,
号 2,
p. 360-366,
発行日 2005-02-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-202X |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1111/j.0022-202X.2004.23583.x |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.nature.com/jid/journal/v124/n2/abs/5602696a.html | http://www.nature.com/jid/journal/v124/n2/abs/5602696a.html |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a putative serine protease inhibitor encoded by serine protease inhibitor Kazal-type 5 (SPINK5). It is strongly expressed in differentiated keratinocytes in normal skin but expression is markedly reduced or absent in Netherton syndrome (NS), a severe ichthyosis caused by SPINK5 mutations. At present, however, both the precise intracellular localization and biological roles of LEKTI are not known. To understand the functional role of LEKTI, we examined the localization of LEKTI together with kallikrein (KLK)7 and KLK5, possible targets of LEKTI, in the human epidermis, by confocal laser scanning microscopy and immunoelectron microscopy. In normal skin, LEKTI, KLK7, and KLK5 were all found in the lamellar granule (LG) system, but were separately localized. LEKTI was expressed earlier than KLK7 and KLK5. In NS skin, LEKTI was absent and an abnormal split in the superficial stratum granulosum was seen in three of four cases. Collectively, these results suggest that in normal skin the LG system transports and secretes LEKTI earlier than KLK7 and KLK5 preventing premature loss of stratum corneum integrity/cohesion. Our data provide new insights into the biological functions of LG and the pathogenesis of NS. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Nature Publishing Group, Journal of Investigative Dermatology, 124, 2, 2005, 360-366
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15675955 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1036 |
792.pdf (1.7 MB)
