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Capillary-resident EphA7+ pericytes are multipotent cells with anti-ischemic effects through capillary formation （EphA7陽性毛細血管周細胞は多分化能を有し、血管形成能を介して、組織虚血を改善する）
https://asahikawa-med.repo.nii.ac.jp/records/6263
https://asahikawa-med.repo.nii.ac.jp/records/6263085f44f3-3ffb-4ece-b87e-e1bf0124eb4e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
7555.pdf (6.5 MB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||||||
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| 公開日 | 2021-04-23 | |||||||||
| タイトル | ||||||||||
| タイトル | Capillary-resident EphA7+ pericytes are multipotent cells with anti-ischemic effects through capillary formation （EphA7陽性毛細血管周細胞は多分化能を有し、血管形成能を介して、組織虚血を改善する） | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | angiogenesis | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | capillary | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | mesenchymal stem cells | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | neuronal stem cells | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | pericytes | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | peripheral ischemic diseases. | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 著者 |
吉田, 有里
× 吉田, 有里
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| 著者 ローマ字 | ||||||||||
| Yoshida, Yuri | ||||||||||
| 書誌情報 |
Stem cells translational medicine 巻 9, 号 1, p. 120-130, 発行日 2020-01-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2157-6564 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1002/sctm.19-0148 | |||||||||
| 識別番号 その他 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | PMID: 31471947 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲546 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2020-03-25 | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関名 | 旭川医科大学 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The presence of pericytes (PCs) with multipotency and broad distribution along capillary suggests that microvasculature plays a role not only as a duct for blood fluid transport but also as a stem cell niche that contributes to tissue maintenance and regeneration. The lack of an appropriate marker for multipotent PCs still limits our understanding of their pathophysiological roles. We identified the novel marker EphA7 to detect multipotent PCs using microarray analysis of an immortalized PC library. PCs were isolated from microvessels of mouse subcutaneous adipose tissues, then EphA7+ PCs called capillary stem cells (CapSCs) were separated from EphA7- control PCs (ctPCs) using fluorescence-activated cell sorting system. CapSCs had highly multipotency that enabled them to differentiate into mesenchymal and neuronal lineages compared with ctPCs. CapSCs also differentiated into endothelial cells and PCs to form capillary-like structures by themselves. Transplantation of CapSCs into ischemic tissues significantly improved blood flow recovery in hind limb ischemia mouse model due to vascular formation compared with that of ctPCs and adipose stromal cells. These data demonstrate that EphA7 identifies a subpopulation of multipotent PCs that have high angiogenesis and regenerative potency and are an attractive target for regenerative therapies. | |||||||||
| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
