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Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention （経皮的冠動脈インターベンション施行患者へのアンジオテンシン受容体拮抗薬による早期の酸化ストレスの抑制は、長期予後に寄与する）
https://asahikawa-med.repo.nii.ac.jp/records/6255
https://asahikawa-med.repo.nii.ac.jp/records/62555b3e284a-6c46-43b7-81c9-9dd0acd8c937
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
7547.pdf (5.2 MB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-23 | |||||
| タイトル | ||||||
| タイトル | Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention （経皮的冠動脈インターベンション施行患者へのアンジオテンシン受容体拮抗薬による早期の酸化ストレスの抑制は、長期予後に寄与する） | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Angiotensin receptor blocker | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PCI | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ROS | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mononuclear cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oxidative stress | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
野呂, 忠孝
× 野呂, 忠孝 |
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| 書誌情報 |
American Journal of Cardiovascular disease 巻 4, 号 4, p. 159-167, 発行日 2014-04-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2160-200X | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID: 25628957 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 乙484 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-03-25 | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 10107 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 旭川医科大学 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: It remains unclear whether administration of ARB with reactive oxygen species (ROS) scavenging effects improves the prognosis of patients undergoing PCI. \nObjectives: This study investigated whether the pre-intervention antioxidant effect of angiotensin receptor blocker (ARB) affects long-term outcomes in patients after successful percutaneous coronary intervention (PCI) without early adverse events. \nMethods: Fifty-two patients who underwent elective PCI were randomly assigned for treatment with or without ARB, which was administered within 48 hours before PCI. ROS levels in mononuclear cells (MNCs) and serum superoxide dismutase (SOD) activity were measured pre-PCI and 6 months post-PCI. After exclusion of unexpected early adverse events during angiographic follow-up period, the long-term outcome (major adverse cerebro-cardiovascular event; MACCE) was assessed in eligible patients. \nResults: Forty-three patients (non-ARB n = 22, ARB n = 21) were followed up in this study. During angiographic follow-up period, ROS formation in MNCs was significantly increased in the non-ARB group (from 29.4 [21.6-35.2] to 37.2 [30.7-45.1] arbitrary units; p = 0.031) compared to that in the ARB group. Meanwhile, SOD activity was significantly impaired in the non-ARB group alone (from 24.0 ± 17.0 to 16.3 ± 13.8%, p = 0.004). During the follow-up period (median, 63.3 months), MACCEs were observed in 6 patients. The cumulative event ratio of MACCE was significantly higher in the non-ARB group than in the ARB group (p = 0.018). \nConclusions: Concomitant administration of ARB effectively reduced ROS production of PCI patients during angiographic follow-up period. Initial ROS inhibition following ARB administration may contribute to improvement of worse outcomes in patients who have undergone successful PCI. |
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| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
