| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2018-12-04 |
| タイトル |
|
|
タイトル |
Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-1 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
corticotropin-releasing factor |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
cytokine |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
gut permeability |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
toll-like receptor 4 |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
visceral pain |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
野津, 司
宮岸, 沙織
野津, 燐太郎
高草木, 薫
奥村, 利勝
|
| 著者 ローマ字 |
|
|
|
en |
|
|
Nozu, Tsukasa |
| 著者 ローマ字 |
|
|
|
en |
|
|
Miyagishi, Saori |
| 著者 ローマ字 |
|
|
|
en |
|
|
Nozu, Rintaro |
| 著者 ローマ字 |
|
|
|
en |
|
|
Takakusaki, Kaoru |
| 著者 ローマ字 |
|
|
|
en |
|
|
Okumura, Toshikatsu |
| bibliographic_information |
en : The Journal of endocrinology
巻 239,
号 2,
p. 241-252,
発行日 2018-11-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0022-0795 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1530/joe-18-0441 |
| item_1716186501932 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
30139928 |
| 識別番号 その他 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
PMID：30139928 |
| item_5_description_33 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Visceral allodynia and increased colonic permeability are considered to be crucial pathophysiology of irritable bowel syndrome (IBS). Corticotropin-releasing factor (CRF) and immune-mediated mechanisms have been proposed to contribute to these changes in IBS, but the precise roles have not been determined. We explored these issues in rats in vivo. The threshold of visceromotor response, i.e., abdominal muscle contractions induced by colonic balloon distention was electrophysiologically measured. Colonic permeability was estimated by quantifying the absorbed Evans blue in colonic tissue. Intraperitoneal injection of CRF increased the permeability, which was blocked by astressin, a non-selective CRF receptor antagonist, but astressin2-B, a selective CRF receptor subtype 2 (CRF2) antagonist did not modify it. Urocortin 2, a selective CRF2 agonist inhibited the increased permeability by CRF. Eritoran, a toll-like receptor 4 (TLR4) antagonist or anakinra, an interleukin-1 receptor antagonist blocked the visceral allodynia and the increased gut permeability induced by CRF. Subcutaneous injection of lipopolysaccharide (immune stress) or repeated water avoidance stress (WAS, psychological stress), 1 h daily for 3 days induced visceral allodynia and increased gut permeability (animal IBS models), which were also blocked by astressin, eritoran or anakinra. In conclusion, stress-induced visceral allodynia and increased colonic permeability were mediated via peripheral CRF receptors. CRF induced these visceral changes via TLR4 and cytokine system, which were CRF1 dependent, and activation of CRF2 inhibited these CRF1-triggered responses. CRF may modulate immune system to alter visceral changes, which are considered to be pivotal pathophysiology of IBS. |
| 出版タイプ |
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出版タイプ |
AM |
| item_5_description_41 |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| item_5_text_44 |
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30139928 |
| item_5_text_54 |
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| item_5_text_55 |
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|
178 |
7141.pdf (770.5 kB)
