| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2018-06-22 |
| タイトル |
|
|
タイトル |
Preservation of chromosomal integrity in murine spermatozoa derived from gonocytes and spermatogonial stem cells surviving prenatal and postnatal exposure to γ‐rays in mice |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
cell death |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
chromosome aberrations |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
radiation |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
spermatogenesis |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
spermatozoa |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
渡部, 浩之
香田, 淳
小村, 潤一郎
立野, 裕幸
|
| 著者 ローマ字 |
|
|
|
Watanabe, Hiroyuki |
| 著者 ローマ字 |
|
|
|
Kohda, Atsushi |
| 著者 ローマ字 |
|
|
|
Komura, Jun-ichiro |
| 著者 ローマ字 |
|
|
|
Tateno, Hiroyuki |
| 書誌情報 |
Molecular reproduction and development
巻 84,
号 7,
p. 638-648,
発行日 2017-07-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1040-452X |
| DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1002/mrd.22832 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
|
内容記述 |
PMID：28481028 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Pre- and postnatal male mice were acutely (659-690 mGy/min) and continuously (0.303 mGy/min) exposed to 2 Gy γ-rays to evaluate spermatogenic potential and chromosome damage in their germ cells as adults. Acute irradiation on Days 15.5, 16.5, and 17.5 post-coitus affected testicular development, as a result of massive quiescent gonocyte loss; the majority of the seminiferous tubules in these testes were devoid of germ cells. Acute irradiation on Days 18.5 and 19.5 post-coitus had less effect on testicular development and spermatogenesis, even though germ cells were quiescent gonocytes on these days. Adverse effects on testicular development and spermatogenesis were observed following continuous irradiation between Days 14.5 and 19.5 post-coitus. Exposure to acute and continuous postnatal irradiation after the differentiation of spermatogonial stem cells and spermatogonia resulted in nearly all of the seminiferous tubules exhibiting spermatogenesis. Neither acute nor continuous irradiation was responsible for the increased number of multivalent chromosomes in primary-spermatocyte descendents of the exposed gonocytes. In contrast, a significant increase in cells with multivalent chromosomes was observed following acute irradiation on Days 4 and 11 post-partum. No significant increases in unstable structural chromosomal aberrations or aneuploidy in spermatozoa were observed, regardless of cell stage at irradiation or the radiation dose-rate. Thus, murine germ cells that survive prenatal and postnatal irradiation can restore spermatogenesis and produce viable spermatozoa without chromosome damage. These findings may provide a better understanding of reproductive potential following accidental, environmental, or therapeutic irradiation during the prenatal and postnatal periods in humans. |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
28481028 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
310 |
7020.pdf (25.8 MB)
