Item type |
学術雑誌論文 / Journal Article_02(1) |
公開日 |
2018-07-26 |
タイトル |
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タイトル |
Pyrazine analogues from wolf urine induced unlearned fear in rats |
言語 |
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言語 |
eng |
キーワード |
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主題Scheme |
Other |
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キーワード |
Neuroscience |
資源タイプ |
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資源タイプ |
journal article |
著者 |
柏柳, 誠
宮園, 貞治
長田, 和実
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著者 ローマ字 |
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Kashiwayanagi, Makoto |
著者 ローマ字 |
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Miyazono, Sadaharu |
著者 ローマ字 |
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Osada, Kazumi |
書誌情報 |
Heliyon
巻 3,
号 8,
p. e00391,
発行日 2017-08-01
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ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2405-8440 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.heliyon.2017.e00391 |
識別番号 その他 |
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内容記述 |
PMID:28920093 |
抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Urine excreted from the common grey wolf (Canis lupus) contains a kairomone, inducing fear-related behaviors in various mammals. Numerous fear-inducing substances activate neurons at the main and/or accessory olfactory bulb (AOB), medial and central amygdala, and hypothalamus. Our previous study showed that the mixture of pyrazine analogues (P-mix) contained in wolf urine induced avoidance and fear-related behaviors in laboratory mice and Hokkaido deer (Cervus nippon yesoensis), a species native to Japan. Exposure to wolf urine or P-mix induced expression of Fos, a marker of neuronal excitation, in the AOB of mice. In the present study, we explored the effects of P-mix on fear-related behaviors and Fos-expression in rats. Exposure to P-mix induced avoidance and immobilization in rats, while that to a mixture of i-amyl acetate, linalool and R(+)-limonene (O-mix), which generate floral and fruity odors, induced avoidance but not immobilization. P-mix but not O-mix increased Fos-immunoreactivity of the AOB, medial and central amygdala, and hypothalamus of rats. The present results suggest that P-mix odor induces unlearned fear-related behaviors in rats. |
注記 |
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内容記述タイプ |
Other |
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注記 |
This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial License 4.0 (CCBY-NC), |
資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
著者版フラグ |
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出版タイプ |
VoR |
フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
ID(XooNIps) |
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28920093 |
閲覧数(XooNIps) |
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ダウンロード数(XooNIps) |
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910 |