| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2018-07-26 |
| タイトル |
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|
タイトル |
Pyrazine analogues from wolf urine induced unlearned fear in rats |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Neuroscience |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
柏柳, 誠
宮園, 貞治
長田, 和実
|
| 著者 ローマ字 |
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Kashiwayanagi, Makoto |
| 著者 ローマ字 |
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Miyazono, Sadaharu |
| 著者 ローマ字 |
|
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Osada, Kazumi |
| 書誌情報 |
Heliyon
巻 3,
号 8,
p. e00391,
発行日 2017-08-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2405-8440 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.heliyon.2017.e00391 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
|
内容記述 |
PMID：28920093 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Urine excreted from the common grey wolf (Canis lupus) contains a kairomone, inducing fear-related behaviors in various mammals. Numerous fear-inducing substances activate neurons at the main and/or accessory olfactory bulb (AOB), medial and central amygdala, and hypothalamus. Our previous study showed that the mixture of pyrazine analogues (P-mix) contained in wolf urine induced avoidance and fear-related behaviors in laboratory mice and Hokkaido deer (Cervus nippon yesoensis), a species native to Japan. Exposure to wolf urine or P-mix induced expression of Fos, a marker of neuronal excitation, in the AOB of mice. In the present study, we explored the effects of P-mix on fear-related behaviors and Fos-expression in rats. Exposure to P-mix induced avoidance and immobilization in rats, while that to a mixture of i-amyl acetate, linalool and R(+)-limonene (O-mix), which generate floral and fruity odors, induced avoidance but not immobilization. P-mix but not O-mix increased Fos-immunoreactivity of the AOB, medial and central amygdala, and hypothalamus of rats. The present results suggest that P-mix odor induces unlearned fear-related behaviors in rats. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial License 4.0 (CCBY-NC), |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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28920093 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
910 |
7035.pdf (1.1 MB)
