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Observation of Zn-photoprotoporphyrin red Autofluorescence in human bronchial cancer using color-fluorescence endoscopy
https://asahikawa-med.repo.nii.ac.jp/records/5895
https://asahikawa-med.repo.nii.ac.jp/records/5895cea4f1ee-5ec1-4923-9764-98b36fa99cf0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
7004.pdf (668.1 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-04 | |||||
| タイトル | ||||||
| タイトル | Observation of Zn-photoprotoporphyrin red Autofluorescence in human bronchial cancer using color-fluorescence endoscopy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Autofluorescence | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Endoscopy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Photodynamic diagnosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prophyrin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Zn-photoprotoporphyrin | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
大崎, 能伸
× 大崎, 能伸× 佐々木, 高明× 遠藤, 哲史× 北田, 正博× 奥村, 俊介× 平井, 理子× 風林, 佳大× 豊嶋, 恵理× 山本, 泰司× 竹山, 周良× 中島, 進× 阪田, 功 |
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| 著者 ローマ字 | ||||||
| 値 | Ohsaki, Yoshinobu | |||||
| 著者 ローマ字 | ||||||
| 値 | Sasaki, Takaaki | |||||
| 著者 ローマ字 | ||||||
| 値 | Endo, Satoshi | |||||
| 著者 ローマ字 | ||||||
| 値 | Kitada, Masahiro | |||||
| 著者 ローマ字 | ||||||
| 値 | Okumura, Shunsuke | |||||
| 著者 ローマ字 | ||||||
| 値 | Hirai, Noriko | |||||
| 著者 ローマ字 | ||||||
| 値 | Kazebayashi, Yoshihiro | |||||
| 著者 ローマ字 | ||||||
| 値 | Toyoshima, Eri | |||||
| 著者 ローマ字 | ||||||
| 値 | Yamamoto, Yasushi | |||||
| 著者 ローマ字 | ||||||
| 値 | Takeyama, Kaneyoshi | |||||
| 著者 ローマ字 | ||||||
| 値 | Nakajima, Susumu | |||||
| 著者 ローマ字 | ||||||
| 値 | Sakata, Isao | |||||
| 書誌情報 |
BMC Cancer 巻 17, 号 1, p. 289, 発行日 2017-04-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1471-2407 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s12885-017-3277-6 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID：28441937 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: \nWe observed red autofluorescence emanating from bronchial cancer lesions using a sensitive color-fluorescence endoscopy system. We investigated to clarify the origin of the red autofluorescence. METHODS: \nThe wavelengths of the red autofluorescence emanating from lesions were measured in eight patients using a spectrum analyzer and compared based on pathologic findings. Red autofluorescence at 617.3, 617.4, 619.0, and 617.1 nm was emitted by normal bronchus, inflamed tissue, tissue exhibiting mild dysplasia, and malignant lesions, respectively. Protoporphyrin, uroporphyrin, and coproporphyrin, the major porphyrin derivatives in human blood, were purchased to determine which porphyrin derivative is the source of red fluorescence when acquired de novo. We synthesized photoporphyrin, Zn-protoporphyrin and Zn-photoprotoporphyrin from protoporphyrin. RESULTS: \nCoproporphyrin and uroporphyrin emitted only weak fluorescence. Fluorescence was emitted by our synthesized Zn-photoprotoporphyrin at 625.5 nm and by photoprotoporphyrin at 664.0 nm. CONCLUSIONS: \nFrom these results, we conclude that Zn-photoprotoporphyrin was the source of the red autofluorescence observed in bronchial lesions. Zn-protoporphyrin is converted to Zn-photoprotoporphyrin by radiation with excitation light. Our results suggest that red autofluorescence emanating from Zn-photoprotoporphyrin in human tissues could interfere with photodynamic diagnosis using porphyrin derivatives such as Photofrin® and Lazerphyrin® with a sensitive endoscopy system, because color cameras cannot differentiate Zn-photoprotoporphyrin red fluorescence from that of other porphyrin derivatives. |
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| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 28441937 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 524 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 613 | |||||
