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Reversed cellular polarity in primary cutaneous mucinous carcinoma: A study on tight junction protein expression in sweat gland tumors.
https://asahikawa-med.repo.nii.ac.jp/records/5892
https://asahikawa-med.repo.nii.ac.jp/records/58928566c53f-9c36-4bab-a53b-18c40497a091
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6963.pdf (615.0 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-27 | |||||
| タイトル | ||||||
| タイトル | Reversed cellular polarity in primary cutaneous mucinous carcinoma: A study on tight junction protein expression in sweat gland tumors. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell polarity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mucinous adenocarcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sweat gland neoplasms | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tight junctions | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
長澤, 有祐
× 長澤, 有祐× 山本, 明美 |
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| 著者 ローマ字 | ||||||
| 値 | Nagasawa, Yusuke | |||||
| 著者 ローマ字 | ||||||
| 値 | Ishida-Yamamoto, Akemi | |||||
| 書誌情報 |
The Journal of dermatology 巻 44, 号 4, p. 444-448, 発行日 2017-04-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0385-2407 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/1346-8138.13611 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Primary cutaneous mucinous carcinoma (PCMC) is a rare sweat gland tumor characterized by the presence of abundant mucin around the tumor islands, but the molecular mechanisms for this structure are not well elucidated. Because mucin is epithelial in nature, it is likely to be produced by epithelial tumor cells, not by surrounding stromal cells. We hypothesized that the abundant mucin is a result of reversed cellular polarity of the tumor. To test this hypothesis, we conducted an immunohistological study to investigate expression of tight junction (TJ) proteins occludin and ZO-1 in PCMC, as well as in normal sweat glands and other sweat gland tumors. Dot-like or linear expression of TJ proteins was observed at ductal structures of sweat glands, and ductal or cystic structures of related tumors. In PCMC, however, TJ protein expression was clearly visible at the edges of tumor cell islands. This study provides evidence to show that the characteristic histological structure of PCMC is caused by inverse polarization of the tumor cells, and that TJ proteins are useful markers of ductal differentiation in sweat gland tumors. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 27649644 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 409 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 382 | |||||
