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A glucagon-like peptide-1 analog, liraglutide improves visceral sensation and gut permeability in rats
https://asahikawa-med.repo.nii.ac.jp/records/5891
https://asahikawa-med.repo.nii.ac.jp/records/5891cce237ff-cd3c-494e-b032-254809d63883
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6716.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-05-19 | |||||
| タイトル | ||||||
| タイトル | A glucagon-like peptide-1 analog, liraglutide improves visceral sensation and gut permeability in rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Colonic permeability | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Liraglutide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Visceral pain | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Water avoidance stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lipopolysaccharide | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
野津, 司
× 野津, 司× 宮岸, 沙織× 粂井, 志麻× 野津, 麟太郎× 高草木, 薫× 奥村, 利勝 |
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| 著者 ローマ字 | ||||||
| 値 | Nozu, Tsukasa | |||||
| 著者 ローマ字 | ||||||
| 値 | Miyagishi, Saori | |||||
| 著者 ローマ字 | ||||||
| 値 | Kumei, Shima | |||||
| 著者 ローマ字 | ||||||
| 値 | Nozu, Rintaro | |||||
| 著者 ローマ字 | ||||||
| 値 | Takakusaki, Kaoru | |||||
| 著者 ローマ字 | ||||||
| 値 | Okumura, Toshikatsu | |||||
| 書誌情報 |
Journal of gastroenterology and hepatology 発行日 2017-04-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0815-9319 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/jgh.13808 | |||||
| リンクURL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://dx.doi.org/10.1111/jgh.13808 | http://dx.doi.org/10.1111/jgh.13808 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID：28440889 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND AND AIM: \nA glucagon-like peptide-1 (GLP-1) analog, liraglutide, has been reported to block inflammatory somatic pain. We hypothesized that liraglutide attenuates lipopolysaccharide (LPS)- and repeated water avoidance stress (WAS)-induced visceral hypersensitivity and tested the hypothesis in rats. METHODS: \nThe threshold of the visceromotor response (VMR) induced by colonic balloon distention was measured to assess visceral sensation. Colonic permeability was determined in vivo by quantifying the absorbed Evans blue spectrophotometrically, which was instilled in the proximal colon for 15 min. The interleukin-6 (IL-6) level in colonic mucosa was also quantified using ELISA. RESULTS: \nSubcutaneously (s.c.) injected LPS (1 mg/kg) reduced the VMR threshold after 3 h. Liraglutide (300 µg/kg s.c.) at 15 h and 30 min before injecting LPS eliminated LPS-induced allodynia. It also blocked the allodynia induced by repeated WAS for 1 h for 3 consecutive days. Neither vagotomy nor naloxone altered the antinociceptive effect of liraglutide, but NG -nitro-L-arginine methyl ester, a nitric oxide (NO) synthesis inhibitor, blocked it. LPS increased colonic permeability and the IL-6 level, and the analog significantly inhibited these responses. CONCLUSIONS: \nThis study suggests that liraglutide blocked LPS-induced visceral allodynia, which may be a NO-dependent response, and was probably mediated by inhibiting proinflammatory cytokine production and attenuating the increased gut permeability. Because the LPS-cytokine system is considered to contribute to altered visceral sensation in irritable bowel syndrome, these results indicate the possibility that liraglutide can be useful for treating this disease. |
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| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Epub2017.4.25 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 28440889 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 706 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 653 | |||||
