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Polymorphism of Receptor-Type Tyrosine-Protein Phosphatase Delta gene is associated with the development and progression of non-alcoholic fatty liver disease.
https://asahikawa-med.repo.nii.ac.jp/records/5740
https://asahikawa-med.repo.nii.ac.jp/records/5740a6737f36-a35a-4967-aac5-b699e8440d46
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6812.pdf (1.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||
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| 公開日 | 2017-10-05 | |||||
| タイトル | ||||||
| タイトル | Polymorphism of Receptor-Type Tyrosine-Protein Phosphatase Delta gene is associated with the development and progression of non-alcoholic fatty liver disease. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PTPRD rs35929428 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | STAT3 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fib-4 index | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | non-alcoholic fatty liver disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | single-nucleotide polymorphism | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
中嶋, 駿介
× 中嶋, 駿介 |
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| 著者 ローマ字 | ||||||
| 値 | Nakajima, Shunsuke | |||||
| 書誌情報 |
Journal of gastroenterology and hepatology 巻 33, 号 1, p. 283-290, 発行日 2018-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0815-9319 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1111/jgh.13820 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID：28497593 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲519 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-09-29 | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 10107 | |||||
| 学位授与機関名 | 旭川医科大学 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND AND AIM: \nSome single-nucleotide polymorphisms (SNPs) are associated with the development of non-alcoholic fatty liver disease (NAFLD). As one of the genetic factors, PNPLA3 rs738409 (I148M) is important to associate with pathogenesis of NAFLD. Because other SNPs remain unclear in Japan, we performed a high-throughput sequencing that targeted more than 1000 genes to identify a novel genetic variant in Japanese patients with NAFLD. METHODS: \nThe present study in 36 NAFLD patients and 27 healthy volunteers was performed. A high-throughput sequencer was used to detect the gene variations. Candidate genes were validated by TaqMan SNP genotyping assay in 53 NAFLD patients and 41 healthy volunteers. To investigate the function of candidate gene, we performed biochemical analyses in cultured hepatocytes and liver tissues. RESULTS: \nEXO1 rs1047840, PTPRD rs35929428, IFNAR2 rs2229207, CPOX rs1131857, IL23R rs1884444, IL10RA rs2228055, and FAM3B rs111988437 were identified as candidate genetic variants, and PTPRD rs35929428 was only extracted as a SNP predicting to cause protein dysfunction. In validation analysis, PTPRD rs35929428 associated with the development of NAFLD (P = 0.015, odds ratio = 5.00, 95% confidence interval: 1.33-18.70). In addition, PTPRD rs35929428 was associated with Fib-4 index and with hepatic fat droplets. Biochemical analyses indicated that PTPRD rs35929428 promoted dephosphorylation of tyrosine 705 signal transducer and activator of transcription 3 (Tyr 705) in hepatocytes. CONCLUSION: \nPTPRD rs35929428 was a novel SNP in patients with NAFLD. Through exacerbation of the dephosphorylation of signal transducer and activator of transcription 3 (Tyr 705) in hepatocytes, PTPRD rs35929428 might play a role in hepatic lipid accumulation and fibrosis, followed by the development of NAFLD. |
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| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
