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Surgical treatment for mediastinal parathyroid adenoma causing primary hyperparathyroidism.

https://asahikawa-med.repo.nii.ac.jp/records/5725
https://asahikawa-med.repo.nii.ac.jp/records/5725
48eaee6f-8288-4114-be9d-f6b6a1fac798
名前 / ファイル ライセンス アクション
6791.pdf 6791.pdf (2.7 MB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2017-09-20
タイトル
タイトル Surgical treatment for mediastinal parathyroid adenoma causing primary hyperparathyroidism.
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 北田, 正博

× 北田, 正博

北田, 正博

ja-Kana キタダ, マサヒロ

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安田, 俊輔

× 安田, 俊輔

安田, 俊輔

ja-Kana ヤスダ, シュンスケ

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高橋, 奈七

× 高橋, 奈七

高橋, 奈七

ja-Kana タカハシ, ナナ

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石橋, 圭

× 石橋, 圭

石橋, 圭

ja-Kana イシバシ, ケイ

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林, 諭史

× 林, 諭史

林, 諭史

ja-Kana ハヤシ, サトシ

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Okazaki, Satoru

× Okazaki, Satoru

Okazaki, Satoru

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著者 ローマ字
Kitada, Masahiro
著者 ローマ字
Yasuda, Shunsuke
著者 ローマ字
Takahasi, Nana
著者 ローマ字
Ishibashi, Kei
著者 ローマ字
Hayashi, Satoshi
書誌情報 Journal of Cardiothoracic Surgery

巻 11, p. 44, 発行日 2016-04-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1749-8090
識別番号 その他
内容記述タイプ Other
内容記述 PMID:27056365
抄録
内容記述タイプ Abstract
内容記述 BACKGROUND:
\nPrimary hyperparathyroidism is a rare disease characterized by excessive secretion of parathyroid hormone from parathyroid adenoma, hyperplasia, or malignancy. The clinical symptoms of the condition are those of hypercalcemia. Although the lesions are commonly located in the neck region, in about 1-2 % of cases, the lesions are ectopically located within the mediastinum, where surgical excision using the cervical approach is difficult. The principal treatment of the condition is surgical excision of the lesion. However, some patients require additional surgery because of recurrence due to intraoperative dissemination. Therefore, safe and accurate excision is essential for the treatment. We reviewed the surgical treatment used at our institution for mediastinal parathyroid adenoma that caused primary hyperparathyroidism.
METHOD:
\nThe subjects were four patients with primary hyperparathyroidism due to mediastinal parathyroid adenoma who underwent surgery at our institution within a period of 10 years, between January 2005 and December 2014. All of the patients were female, with a mean age of 64.5 years (range, 55-74 years). The examined variables included background factors, clinical condition, surgical method, and clinical outcome.
RESULT:
\nIn all of the patients, primary hyperparathyroidism was detected with symptoms of hypercalcemia. Laboratory tests revealed a mean serum calcium level of 11.85 mg/dL (range, 11.2-13.2 mg/dL) and a mean parathyroid hormone (intact PTH) level of 304.8 pg/mL (range, 126-586 pg/mL), indicating elevated levels for all patients. Chest computed tomography (CT) revealed tumors with a mean diameter of 2.8 cm (range, 10-45 mm) in the anterior mediastinum in all of the patients. On 99mTC-methoxy isobutyl isonitrile (MIBI) scintigraphy, abnormal accumulation was observed in all of the patients. Regarding the surgical methods, median sternotomy was used for three cases and upper partial sternotomy was used for one case. The surgery was safely and accurately performed, without postoperative complications. After surgery, the serum calcium levels immediately returned to normal and the symptoms improved.
CONCLUSION:
\nWe performed excision safely and accurately in all of the patients. In tumor identification, 99mTC-MIBI scintigraphy was useful. Accurate tumor identification and selection of the optimal surgical method are important for prevention of recurrence due to intraoperative dissemination.
注記
内容記述タイプ Other
注記 This is an open access article distributed under the terms of the Creative Commons Attribution License
資源タイプ
内容記述タイプ Other
資源タイプ text
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出版タイプ VoR
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内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
27056365
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ダウンロード数(XooNIps)
663
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