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However, higher DEX concentrations are considered to be required for sedation and/or pain management after major surgery using remifentanil. We determined the DEX concentration required after major surgery by using a target-controlled infusion (TCI) system for DEX.\nMETHODS:\n\\nFourteen patients undergoing surgery for abdominal aortic aneurysms (AAA) were randomly, double-blindly assigned to two groups and underwent fentanyl- or remifentanil-based anesthetic management. DEX TCI was started at the time of closing the peritoneum and continued for 12 hours after stopping propofol administration (M0); DEX TCI was adjusted according to the sedation score and complaints of pain. The doses and concentrations of all anesthetics and postoperative conditions were investigated.\nRESULTS:\n\\nThroughout the observation period, the predicted plasma concentration of DEX in the fentanyl group was stable at approximately 0.7 ng/mL. 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The dexmedetomidine concentration required after remifentanil anesthesia is three-fold higher than that after fentanyl anesthesia or that for general sedation in the ICU.
https://asahikawa-med.repo.nii.ac.jp/records/5710
https://asahikawa-med.repo.nii.ac.jp/records/5710c06eeae3-62ad-4c72-81c7-e5aacfc48c55
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2017-09-06 | |||||
タイトル | ||||||
タイトル | The dexmedetomidine concentration required after remifentanil anesthesia is three-fold higher than that after fentanyl anesthesia or that for general sedation in the ICU. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | abdominal aortic aneurysms (AAA) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | dopamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | effect-site concentration (ESC) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | plasma concentration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | target-controlled infusion (TCI) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | urine output | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
国沢, 卓之
× 国沢, 卓之× 藤本, 一弘× 黒澤, 温× 長島, 道生× 松井, 康二× 林, 大× 山本, 邦彦× 後藤, 祐也× 阿久津, 弘明× 岩崎, 寛 |
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著者 ローマ字 | ||||||
Kunisawa, Takayuki | ||||||
著者 ローマ字 | ||||||
Fujimoto, Kazuhiro | ||||||
著者 ローマ字 | ||||||
Kurosawa, Atsushi | ||||||
著者 ローマ字 | ||||||
Nagashima, Michio | ||||||
著者 ローマ字 | ||||||
Matsui, Koji | ||||||
著者 ローマ字 | ||||||
Hayashi, Dai | ||||||
著者 ローマ字 | ||||||
Yamamoto, Kunihiko | ||||||
著者 ローマ字 | ||||||
Goto, Yuya | ||||||
著者 ローマ字 | ||||||
Akutsu, Hiroaki | ||||||
著者 ローマ字 | ||||||
Iwasaki, Hiroshi | ||||||
書誌情報 |
Therapeutics and Clinical Risk Management 号 10, p. 797-806, 発行日 2014-10-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1176-6336 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/TCRM.S67211 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: \nThe general dexmedetomidine (DEX) concentration required for sedation of intensive care unit patients is considered to be approximately 0.7 ng/mL. However, higher DEX concentrations are considered to be required for sedation and/or pain management after major surgery using remifentanil. We determined the DEX concentration required after major surgery by using a target-controlled infusion (TCI) system for DEX. METHODS: \nFourteen patients undergoing surgery for abdominal aortic aneurysms (AAA) were randomly, double-blindly assigned to two groups and underwent fentanyl- or remifentanil-based anesthetic management. DEX TCI was started at the time of closing the peritoneum and continued for 12 hours after stopping propofol administration (M0); DEX TCI was adjusted according to the sedation score and complaints of pain. The doses and concentrations of all anesthetics and postoperative conditions were investigated. RESULTS: \nThroughout the observation period, the predicted plasma concentration of DEX in the fentanyl group was stable at approximately 0.7 ng/mL. In contrast, the predicted plasma concentration of DEX in the remifentanil group rapidly increased and stabilized at approximately 2 ng/mL. The actual DEX concentration at 540 minutes after M0 showed a similar trend (0.54±0.14 [fentanyl] versus 1.57±0.39 ng/mL [remifentanil]). In the remifentanil group, the dopamine dose required and the duration of intubation decreased, and urine output increased; however, no other outcomes improved. CONCLUSION: \nThe DEX concentration required after AAA surgery with remifentanil was three-fold higher than that required after AAA surgery with fentanyl or the conventional DEX concentration for sedation. High DEX concentration after remifentanil affords some benefits in anesthetic management. |
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注記 | ||||||
内容記述タイプ | Other | |||||
注記 | This articles under a Creative Commons Attribution Non-Commercial license (CC-BY-NC). | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
資源タイプ | text | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
23528935 | ||||||
閲覧数(XooNIps) | ||||||
445 | ||||||
ダウンロード数(XooNIps) | ||||||
962 |