| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2017-09-06 |
| タイトル |
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タイトル |
The dexmedetomidine concentration required after remifentanil anesthesia is three-fold higher than that after fentanyl anesthesia or that for general sedation in the ICU. |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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キーワード |
abdominal aortic aneurysms (AAA) |
| キーワード |
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主題Scheme |
Other |
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キーワード |
dopamine |
| キーワード |
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主題Scheme |
Other |
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キーワード |
effect-site concentration (ESC) |
| キーワード |
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主題Scheme |
Other |
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キーワード |
plasma concentration |
| キーワード |
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主題Scheme |
Other |
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キーワード |
target-controlled infusion (TCI) |
| キーワード |
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主題Scheme |
Other |
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キーワード |
urine output |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
国沢, 卓之
藤本, 一弘
黒澤, 温
長島, 道生
松井, 康二
林, 大
山本, 邦彦
後藤, 祐也
阿久津, 弘明
岩崎, 寛
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| 著者 ローマ字 |
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Kunisawa, Takayuki |
| 著者 ローマ字 |
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Fujimoto, Kazuhiro |
| 著者 ローマ字 |
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Kurosawa, Atsushi |
| 著者 ローマ字 |
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Nagashima, Michio |
| 著者 ローマ字 |
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Matsui, Koji |
| 著者 ローマ字 |
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Hayashi, Dai |
| 著者 ローマ字 |
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Yamamoto, Kunihiko |
| 著者 ローマ字 |
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Goto, Yuya |
| 著者 ローマ字 |
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Akutsu, Hiroaki |
| 著者 ローマ字 |
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Iwasaki, Hiroshi |
| 書誌情報 |
Therapeutics and Clinical Risk Management
号 10,
p. 797-806,
発行日 2014-10-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1176-6336 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.2147/TCRM.S67211 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
PURPOSE:
\nThe general dexmedetomidine (DEX) concentration required for sedation of intensive care unit patients is considered to be approximately 0.7 ng/mL. However, higher DEX concentrations are considered to be required for sedation and/or pain management after major surgery using remifentanil. We determined the DEX concentration required after major surgery by using a target-controlled infusion (TCI) system for DEX.
METHODS:
\nFourteen patients undergoing surgery for abdominal aortic aneurysms (AAA) were randomly, double-blindly assigned to two groups and underwent fentanyl- or remifentanil-based anesthetic management. DEX TCI was started at the time of closing the peritoneum and continued for 12 hours after stopping propofol administration (M0); DEX TCI was adjusted according to the sedation score and complaints of pain. The doses and concentrations of all anesthetics and postoperative conditions were investigated.
RESULTS:
\nThroughout the observation period, the predicted plasma concentration of DEX in the fentanyl group was stable at approximately 0.7 ng/mL. In contrast, the predicted plasma concentration of DEX in the remifentanil group rapidly increased and stabilized at approximately 2 ng/mL. The actual DEX concentration at 540 minutes after M0 showed a similar trend (0.54±0.14 [fentanyl] versus 1.57±0.39 ng/mL [remifentanil]). In the remifentanil group, the dopamine dose required and the duration of intubation decreased, and urine output increased; however, no other outcomes improved.
CONCLUSION:
\nThe DEX concentration required after AAA surgery with remifentanil was three-fold higher than that required after AAA surgery with fentanyl or the conventional DEX concentration for sedation. High DEX concentration after remifentanil affords some benefits in anesthetic management. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
This articles under a Creative Commons Attribution Non-Commercial license (CC-BY-NC). |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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23528935 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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962 |
6775.pdf (443.2 kB)
