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The dexmedetomidine concentration required after remifentanil anesthesia is three-fold higher than that after fentanyl anesthesia or that for general sedation in the ICU.
https://asahikawa-med.repo.nii.ac.jp/records/5710
https://asahikawa-med.repo.nii.ac.jp/records/5710c06eeae3-62ad-4c72-81c7-e5aacfc48c55
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6775.pdf (443.2 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-09-06 | |||||
| タイトル | ||||||
| タイトル | The dexmedetomidine concentration required after remifentanil anesthesia is three-fold higher than that after fentanyl anesthesia or that for general sedation in the ICU. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | abdominal aortic aneurysms (AAA) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dopamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | effect-site concentration (ESC) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | plasma concentration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | target-controlled infusion (TCI) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | urine output | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
国沢, 卓之
× 国沢, 卓之× 藤本, 一弘× 黒澤, 温× 長島, 道生× 松井, 康二× 林, 大× 山本, 邦彦× 後藤, 祐也× 阿久津, 弘明× 岩崎, 寛 |
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| 著者 ローマ字 | ||||||
| 値 | Kunisawa, Takayuki | |||||
| 著者 ローマ字 | ||||||
| 値 | Fujimoto, Kazuhiro | |||||
| 著者 ローマ字 | ||||||
| 値 | Kurosawa, Atsushi | |||||
| 著者 ローマ字 | ||||||
| 値 | Nagashima, Michio | |||||
| 著者 ローマ字 | ||||||
| 値 | Matsui, Koji | |||||
| 著者 ローマ字 | ||||||
| 値 | Hayashi, Dai | |||||
| 著者 ローマ字 | ||||||
| 値 | Yamamoto, Kunihiko | |||||
| 著者 ローマ字 | ||||||
| 値 | Goto, Yuya | |||||
| 著者 ローマ字 | ||||||
| 値 | Akutsu, Hiroaki | |||||
| 著者 ローマ字 | ||||||
| 値 | Iwasaki, Hiroshi | |||||
| 書誌情報 |
Therapeutics and Clinical Risk Management 号 10, p. 797-806, 発行日 2014-10-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1176-6336 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2147/TCRM.S67211 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: \nThe general dexmedetomidine (DEX) concentration required for sedation of intensive care unit patients is considered to be approximately 0.7 ng/mL. However, higher DEX concentrations are considered to be required for sedation and/or pain management after major surgery using remifentanil. We determined the DEX concentration required after major surgery by using a target-controlled infusion (TCI) system for DEX. METHODS: \nFourteen patients undergoing surgery for abdominal aortic aneurysms (AAA) were randomly, double-blindly assigned to two groups and underwent fentanyl- or remifentanil-based anesthetic management. DEX TCI was started at the time of closing the peritoneum and continued for 12 hours after stopping propofol administration (M0); DEX TCI was adjusted according to the sedation score and complaints of pain. The doses and concentrations of all anesthetics and postoperative conditions were investigated. RESULTS: \nThroughout the observation period, the predicted plasma concentration of DEX in the fentanyl group was stable at approximately 0.7 ng/mL. In contrast, the predicted plasma concentration of DEX in the remifentanil group rapidly increased and stabilized at approximately 2 ng/mL. The actual DEX concentration at 540 minutes after M0 showed a similar trend (0.54±0.14 [fentanyl] versus 1.57±0.39 ng/mL [remifentanil]). In the remifentanil group, the dopamine dose required and the duration of intubation decreased, and urine output increased; however, no other outcomes improved. CONCLUSION: \nThe DEX concentration required after AAA surgery with remifentanil was three-fold higher than that required after AAA surgery with fentanyl or the conventional DEX concentration for sedation. High DEX concentration after remifentanil affords some benefits in anesthetic management. |
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| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This articles under a Creative Commons Attribution Non-Commercial license (CC-BY-NC). | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 23528935 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 445 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 962 | |||||
