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Scanning Electron Microscopy Findings of Machine Perfused Liver Graft After Warm Ischemia Between Hypothermic and Rewarming Machine Perfusion in Pigs.
https://asahikawa-med.repo.nii.ac.jp/records/5700
https://asahikawa-med.repo.nii.ac.jp/records/5700ddcde199-518a-4510-8a40-d86a5f781d75
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6760.pdf (3.0 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2017-07-21 | |||||
| タイトル | ||||||
| タイトル | Scanning Electron Microscopy Findings of Machine Perfused Liver Graft After Warm Ischemia Between Hypothermic and Rewarming Machine Perfusion in Pigs. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Meng, Lingtong
× Meng, Lingtong× 松野, 直徒× 渡邉, 賢二× 古郡, 茉里子× 小原, 弘道× 暮地本, 宙己× 渡辺, 剛× 古川, 博之 |
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| 著者 ローマ字 | ||||||
| 著者 ローマ字 | ||||||
| 値 | Matsuno, Naoto | |||||
| 著者 ローマ字 | ||||||
| 値 | Watanabe, Kenji | |||||
| 著者 ローマ字 | ||||||
| 値 | Furukori, Mariko | |||||
| 著者 ローマ字 | ||||||
| 値 | Obara, Hiromichi | |||||
| 著者 ローマ字 | ||||||
| 値 | Bochimoto, Hiroki | |||||
| 著者 ローマ字 | ||||||
| 値 | Watanabe, Tsuyoshi | |||||
| 著者 ローマ字 | ||||||
| 値 | Furukawa, Hiroyuki | |||||
| 書誌情報 |
Transplantation Proceedings 巻 48, 号 7, p. 2467-2470, 発行日 2016-09-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0041-1345 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.transproceed.2016.03.059 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: \nThe shortage of organ donors is a universal problem. Use of grafts from donors after cardiac death would greatly contribute to the expansion of the donor organ pool. The two major methods of preservation are cold storage and machine perfusion (MP) preservation, and each has its own advantages. Several studies have reported the relative merits of MP for the preservation for grafts from donors after cardiac death. In this study, we used scanning electron microscopy (SEM) to assess the damage to the liver between hypothermic and rewarming preservation conditions. METHODS: \nPorcine livers were perfused with a newly developed MP system. The livers were perfused for 4 hours with a modified University of Wisconsin solution-gluconate solution. In group 1, grafts were preserved with warm ischemic time for 60 minutes and hypothermic machine perfusion (HMP) for 4 hours. In group 2, grafts were preserved with warn ischemic time for 60 minutes and had rewarming up to 22°C by MP (RMP) for 4 hours. RESULTS: \nA significant enlargement of the mitochondria were observed in both the HMP and RMP groups under higher magnification, Additionally, vacuoles appeared occasionally in hepatocytes in the RMP for 4 hours group, but not in the HMP for 4 hours group. CONCLUSIONS: \nAn analysis by scanning electron microscope appears to be useful to evaluate the levels of damage of hepatocytes compared with transmission electron microscopy, and further study is needed to analyze the significance of the appearance of swelling of mitochondria and vacuolization during preservation. |
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| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 27742324 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 436 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 650 | |||||
