WEKO3
アイテム
{"_buckets": {"deposit": "4816c643-b268-4c67-a9a6-a263ccb4a440"}, "_deposit": {"created_by": 3, "id": "5686", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "5686"}, "status": "published"}, "_oai": {"id": "oai:asahikawa-med.repo.nii.ac.jp:00005686", "sets": ["7", "41"]}, "author_link": ["17731"], "item_10_alternative_title_3": {"attribute_name": "その他(別言語等)のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "妊娠はTNF-αの抑制を介して,絞扼性神経損傷モデルラットの神経障害性疼痛を抑制する"}]}, "item_10_biblio_info_21": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-01", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "574", "bibliographicPageStart": "567", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{"bibliographic_title": "Journal of pain research"}]}]}, "item_10_date_granted_30": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-06-30"}]}, "item_10_degree_grantor_32": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "旭川医科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "10107", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_10_degree_name_31": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_10_description_28": {"attribute_name": "識別番号 その他", "attribute_value_mlt": [{"subitem_description": "PMID:28331359", "subitem_description_type": "Other"}]}, "item_10_description_33": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "PURPOSE:\n\\nPregnancy-induced analgesia develops during late pregnancy, but it is unclear whether this analgesia is effective against neuropathic pain. The detailed molecular mechanisms underlying pregnancy-induced analgesia have not been investigated. We examined the antinociceptive effect of pregnancy-induced analgesia in a neuropathic pain model and the expression of tumor necrosis factor (TNF)-α, glial fibrillary acidic protein (GFAP), Iba-1, and c-Fos in the spinal dorsal horn just before parturition.\nMATERIALS AND METHODS:\n\\nFemale Sprague Dawley rats (200-250 g) were randomly assigned to one of four groups (pregnant + chronic constriction injury [CCI]; pregnant + sham injury; not pregnant + CCI; and not pregnant + sham injury). Separate groups were used for the behavioral and tissue analyses. CCI of the left sciatic nerve was surgically induced 3 days after confirming pregnancy in the pregnancy group or on day 3 in the not pregnant group. The spinal cord was extracted 18 days after CCI. TNF-α, GFAP, Iba-1, and c-Fos expression levels in the spinal dorsal horn were measured by Western blot analysis. Mechanical threshold was tested using von Frey filaments.\nRESULTS:\n\\nThe lowered mechanical threshold induced by CCI was significantly attenuated within 1 day before parturition and decreased after delivery. TNF-α expression in CCI rats was decreased within 1 day before parturition. Further, GFAP, Iba-1, and c-Fos expression in the spinal dorsal horn was reduced in the pregnant rats. Serum TNF-α in all groups was below measurable limits.\nCONCLUSION:\n\\nOur findings indicate that pregnancy-induced analgesia suppresses neuropathic pain through reducing spinal levels of TNF-α, GFAP, Iba-1, and c-Fos in a rat model of CCI.", "subitem_description_type": "Abstract"}]}, "item_10_description_37": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10_description_41": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10_dissertation_number_29": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲513"}]}, "item_10_relation_24": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2147/JPR.S121810", "subitem_relation_type_select": "DOI"}}]}, "item_10_source_id_22": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1178-7090", "subitem_source_identifier_type": "ISSN"}]}, "item_10_text_44": {"attribute_name": "ID(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "20170630_K513"}]}, "item_10_text_51": {"attribute_name": "最終更新日(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "Jul 3, 2017 15:38:56"}]}, "item_10_text_52": {"attribute_name": "更新履歴(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "Jul 3, 2017 別タイトル を変更"}]}, "item_10_text_53": {"attribute_name": "登録者(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "Library"}]}, "item_10_text_54": {"attribute_name": "閲覧数(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "638"}]}, "item_10_text_55": {"attribute_name": "ダウンロード数(XooNIps)", "attribute_value_mlt": [{"subitem_text_value": "592"}]}, "item_10_text_56": {"attribute_name": "XooNIps_ITEM_KEY", "attribute_value_mlt": [{"subitem_text_value": "6744"}]}, "item_10_text_7": {"attribute_name": "著者 ローマ字", "attribute_value_mlt": [{"subitem_text_value": "Onodera, Yoshiko"}]}, "item_10_version_type_38": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小野寺, 美子", "creatorNameLang": "ja"}, {"creatorName": "オノデラ, ヨシコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "17731", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-07-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "6744.pdf", "filesize": [{"value": "894.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 894200.0, "url": {"label": "6744.pdf", "url": "https://asahikawa-med.repo.nii.ac.jp/record/5686/files/6744.pdf"}, "version_id": "8fe08353-8633-4dcb-850f-9fa4fff44f2c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "TNF-α", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glial cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neuropathic pain", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pregnancy-induced analgesia", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α.", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "3", "path": ["6", "7", "41"], "permalink_uri": "https://asahikawa-med.repo.nii.ac.jp/records/5686", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-06-30"}, "publish_date": "2017-06-30", "publish_status": "0", "recid": "5686", "relation": {}, "relation_version_is_last": true, "title": ["Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α."], "weko_shared_id": -1}
Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α.
https://asahikawa-med.repo.nii.ac.jp/records/5686
https://asahikawa-med.repo.nii.ac.jp/records/5686fe3512cc-8408-4070-89d8-479604c9cf93
名前 / ファイル | ライセンス | アクション |
---|---|---|
6744.pdf (894.2 kB)
|
|
Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-06-30 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | TNF-α | |||||
キーワード | ||||||
主題 | glial cell | |||||
キーワード | ||||||
主題 | neuropathic pain | |||||
キーワード | ||||||
主題 | pregnancy-induced analgesia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | 妊娠はTNF-αの抑制を介して,絞扼性神経損傷モデルラットの神経障害性疼痛を抑制する | |||||
著者 |
小野寺, 美子
× 小野寺, 美子 |
|||||
著者 ローマ字 | ||||||
Onodera, Yoshiko | ||||||
書誌情報 |
Journal of pain research 巻 10, p. 567-574, 発行日 2017-03-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1178-7090 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/JPR.S121810 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:28331359 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲513 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-06-30 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 旭川医科大学 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: \nPregnancy-induced analgesia develops during late pregnancy, but it is unclear whether this analgesia is effective against neuropathic pain. The detailed molecular mechanisms underlying pregnancy-induced analgesia have not been investigated. We examined the antinociceptive effect of pregnancy-induced analgesia in a neuropathic pain model and the expression of tumor necrosis factor (TNF)-α, glial fibrillary acidic protein (GFAP), Iba-1, and c-Fos in the spinal dorsal horn just before parturition. MATERIALS AND METHODS: \nFemale Sprague Dawley rats (200-250 g) were randomly assigned to one of four groups (pregnant + chronic constriction injury [CCI]; pregnant + sham injury; not pregnant + CCI; and not pregnant + sham injury). Separate groups were used for the behavioral and tissue analyses. CCI of the left sciatic nerve was surgically induced 3 days after confirming pregnancy in the pregnancy group or on day 3 in the not pregnant group. The spinal cord was extracted 18 days after CCI. TNF-α, GFAP, Iba-1, and c-Fos expression levels in the spinal dorsal horn were measured by Western blot analysis. Mechanical threshold was tested using von Frey filaments. RESULTS: \nThe lowered mechanical threshold induced by CCI was significantly attenuated within 1 day before parturition and decreased after delivery. TNF-α expression in CCI rats was decreased within 1 day before parturition. Further, GFAP, Iba-1, and c-Fos expression in the spinal dorsal horn was reduced in the pregnant rats. Serum TNF-α in all groups was below measurable limits. CONCLUSION: \nOur findings indicate that pregnancy-induced analgesia suppresses neuropathic pain through reducing spinal levels of TNF-α, GFAP, Iba-1, and c-Fos in a rat model of CCI. |
|||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |