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Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α.
https://asahikawa-med.repo.nii.ac.jp/records/5686
https://asahikawa-med.repo.nii.ac.jp/records/5686fe3512cc-8408-4070-89d8-479604c9cf93
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6744.pdf (894.2 kB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||||||
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| 公開日 | 2017-06-30 | |||||||||
| タイトル | ||||||||||
| タイトル | Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α. | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | TNF-α | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | glial cell | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | neuropathic pain | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | pregnancy-induced analgesia | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| その他（別言語等）のタイトル | ||||||||||
| その他のタイトル | 妊娠はTNF-αの抑制を介して，絞扼性神経損傷モデルラットの神経障害性疼痛を抑制する | |||||||||
| 著者 |
小野寺, 美子
× 小野寺, 美子
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| 著者 ローマ字 | ||||||||||
| Onodera, Yoshiko | ||||||||||
| 書誌情報 |
Journal of pain research 巻 10, p. 567-574, 発行日 2017-03-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1178-7090 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.2147/JPR.S121810 | |||||||||
| 識別番号 その他 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | PMID：28331359 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲513 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2017-06-30 | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関名 | 旭川医科大学 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | PURPOSE: \nPregnancy-induced analgesia develops during late pregnancy, but it is unclear whether this analgesia is effective against neuropathic pain. The detailed molecular mechanisms underlying pregnancy-induced analgesia have not been investigated. We examined the antinociceptive effect of pregnancy-induced analgesia in a neuropathic pain model and the expression of tumor necrosis factor (TNF)-α, glial fibrillary acidic protein (GFAP), Iba-1, and c-Fos in the spinal dorsal horn just before parturition. MATERIALS AND METHODS: \nFemale Sprague Dawley rats (200-250 g) were randomly assigned to one of four groups (pregnant + chronic constriction injury [CCI]; pregnant + sham injury; not pregnant + CCI; and not pregnant + sham injury). Separate groups were used for the behavioral and tissue analyses. CCI of the left sciatic nerve was surgically induced 3 days after confirming pregnancy in the pregnancy group or on day 3 in the not pregnant group. The spinal cord was extracted 18 days after CCI. TNF-α, GFAP, Iba-1, and c-Fos expression levels in the spinal dorsal horn were measured by Western blot analysis. Mechanical threshold was tested using von Frey filaments. RESULTS: \nThe lowered mechanical threshold induced by CCI was significantly attenuated within 1 day before parturition and decreased after delivery. TNF-α expression in CCI rats was decreased within 1 day before parturition. Further, GFAP, Iba-1, and c-Fos expression in the spinal dorsal horn was reduced in the pregnant rats. Serum TNF-α in all groups was below measurable limits. CONCLUSION: \nOur findings indicate that pregnancy-induced analgesia suppresses neuropathic pain through reducing spinal levels of TNF-α, GFAP, Iba-1, and c-Fos in a rat model of CCI. |
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| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
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| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
