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Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats
https://asahikawa-med.repo.nii.ac.jp/records/5663
https://asahikawa-med.repo.nii.ac.jp/records/5663e803cb4f-9c41-4fe0-8a5b-b02cc3feda65
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2016-04-18 | |||||
タイトル | ||||||
タイトル | Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Visceral allodynia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | LPS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CRF | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-6 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
野津, 司
× 野津, 司× 宮岸, 沙織× Nozu, Rintaro× 高草木, 薫× 奥村, 利勝 |
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著者 ローマ字 | ||||||
値 | Nozu, Tsukasa | |||||
著者 ローマ字 | ||||||
値 | Miyagishi, Saori | |||||
著者 ローマ字 | ||||||
著者 ローマ字 | ||||||
値 | Takakusaki, Kaoru | |||||
著者 ローマ字 | ||||||
値 | Okumura, Toshikatsu | |||||
書誌情報 |
Journal of Gastroenterology p. 1-9, 発行日 2016-04-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0944-1174 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00535-016-1208-y | |||||
リンクURL | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://link.springer.com/article/10.1007%2Fs00535-016-1208-y | http://link.springer.com/article/10.1007%2Fs00535-016-1208-y | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:27075754 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: \nLipopolysaccharide (LPS) induces visceral hypersensitivity, and corticotropin-releasing factor (CRF) also modulates visceral sensation. Besides, LPS increases CRF immunoreactivity in rat colon, which raises the possibility of the existence of a link between LPS and the CRF system in modulating visceral sensation. The present study tried to clarify this possibility. METHODS: \nVisceral sensation was assessed by abdominal muscle contractions induced by colonic balloon distention, i.e., visceromotor response, electrophysiologically in conscious rats. The threshold of visceromotor response was measured before and after administration of drugs. RESULTS: \nLPS at a dose of 1 mg/kg subcutaneously (sc) decreased the threshold at 3 h after the administration. Intraperitoneal (ip) administration of anakinra (20 mg/kg), an interleukin-1 (IL-1) receptor antagonist, or interleukin-6 (IL-6) antibody (16.6 µg/kg) blocked this effect. Additionally, IL-1β (10 µg/kg, sc) or IL-6 (10 µg/kg, sc) induced visceral allodynia. Astressin (200 µg/kg, ip), a non-selective CRF receptor antagonist, abolished the effect of LPS, but astressin2-B (200 µg/kg, ip), a CRF receptor type 2 (CRF2) antagonist, did not alter it. Peripheral CRF receptor type 1 (CRF1) stimulation by cortagine (60 µg/kg, ip) exaggerated the effect of LPS, but activation of CRF2 by urocortin 2 (60 µg/kg, ip) abolished it. CONCLUSIONS: \nLPS induced visceral allodynia possibly through stimulating IL-1 and IL-6 release. In addition, this effect was mediated through peripheral CRF signaling. Since the LPS-cytokine system is thought to contribute to altered visceral sensation in the patients with irritable bowel syndrome, these results may further suggest that CRF plays a crucial role in the pathophysiology of this disease. |
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注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | “The final publication is available at Springer via http://10.1007/s00535-016-1208-y” | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | 27075754 | |||||
閲覧数(XooNIps) | ||||||
値 | 554 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 1635 |