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Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats.
https://asahikawa-med.repo.nii.ac.jp/records/5639
https://asahikawa-med.repo.nii.ac.jp/records/56393759cfe4-8f2d-4ed4-a8c2-bedc6af74b29
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6266.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2015-12-16 | |||||
| タイトル | ||||||
| タイトル | Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | corticotropin releasing factor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dopamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hyposensitivity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | visceral sensation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | water avoidance stress | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
野津, 司
× 野津, 司× 宮岸, 沙織× Nozu, Rintaro× 高草木, 薫× 奥村, 利勝 |
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| 著者 ローマ字 | ||||||
| 値 | Nozu, Tsukasa | |||||
| 著者 ローマ字 | ||||||
| 値 | Miyagishi, Saori | |||||
| 著者 ローマ字 | ||||||
| 著者 ローマ字 | ||||||
| 値 | Takakusaki, Kaoru | |||||
| 著者 ローマ字 | ||||||
| 値 | Okumura, Toshikatsu | |||||
| 書誌情報 |
Neurogastroenterology and Motility 巻 28, 号 4, p. 522-531, 発行日 2016-04-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1350-1925 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/nmo.12747 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:26662216 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: \nWater avoidance stress (WAS) is reported to induce functional changes in visceral sensory function in rodents, but the results which have been demonstrated so far are not consistent, i.e., hypersensitivity or hyposensitivity. We determined the effect of WAS on visceral sensation and evaluated the mechanisms of the action. METHODS: \nVisceral sensation was assessed by abdominal muscle contractions induced by colonic balloon distention, i.e., visceromotor response (VMR), measured electrophysiologically in conscious rats. The electromyogram electrodes were acutely implanted under anesthesia on the day of the experiment. The threshold of VMR was measured before and after WAS for 1 h. To explore the mechanisms of WAS-induced response, drugs were administered 10 min prior to the initiation of WAS. KEY RESULTS: \nWAS significantly increased the threshold of VMR, and this effect was no longer detected at 24 h after. Intraperitoneal injection of astressin2 -B (200 μg/kg), a corticotropin releasing factor (CRF) receptor type 2 antagonist abolished the response by WAS. Subcutaneous (sc) injection of sulpiride (200 mg/kg), a dopamine D2 receptor antagonist blocked the response, while sc domperidone (10 mg/kg), a peripheral dopamine D2 receptor antagonist did not alter it. Naloxone (1 mg/kg, sc), an opioid antagonist did not modify it either. CONCLUSIONS & INFERENCES: \nWAS induced visceral hyposensitivity through peripheral CRF receptor type 2 and central dopamine D2 receptor, but not through opioid pathways. As altered pain inhibitory system was reported to be observed in the patients with irritable bowel syndrome, CRF and dopamine signaling might contribute to the pathophysiology. |
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| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Epub2015.12 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 26662216 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 531 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 693 | |||||
