| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2015-08-17 |
| タイトル |
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タイトル |
Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis. |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
嘉島, 伸
藤谷, 幹浩
小西, 弘晃
上野, 伸展
稲場, 勇平
盛一, 健太郎
田邊, 裕貴
生田, 克哉
大竹, 孝明
高後, 裕
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| 著者 ローマ字 |
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Kashima, Shin |
| 著者 ローマ字 |
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Fujiya, Mikihiro |
| 著者 ローマ字 |
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Konishi, Hiroaki |
| 著者 ローマ字 |
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Ueno, Nobuhiro |
| 著者 ローマ字 |
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Inaba, Yuhei |
| 著者 ローマ字 |
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Moriichi, Kentaro |
| 著者 ローマ字 |
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Tanabe, Hiroki |
| 著者 ローマ字 |
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Ikuta, Katsuya |
| 著者 ローマ字 |
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Ohtake, Takaaki |
| 著者 ローマ字 |
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Kohgo, Yutaka |
| 書誌情報 |
Translational Research
巻 166,
号 2,
p. 163-175,
発行日 2015-08-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1931-5244 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.trsl.2015.02.002. |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:25766132 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Inflammatory bowel disease frequently causes intestinal obstruction because of extensive fibrosis. This study investigated whether polyphosphate (poly P), an active molecule derived from Lactobacillus brevis, could improve the fibrosis in a model of chronic colitis. In this study, dextran sodium sulfate (DSS)-induced chronic colitis models and trinitrobenzene sulfonic acid (TNBS)-induced colitis models were used as models of fibrosis. To clarify the mechanism responsible for the observed effects, Caco-2/brush border epithelial (BBE) and naive T helper lymphocyte (THP)-1 cells were treated with lipopolysaccharide (LPS) to induce inflammation. Non-cancer human colon fibroblast (CCD-18) cells were treated with transforming growth factor beta 1 (TGF-β1) to induce fibrosis. The expression levels of fibrosis- and inflammation-associated molecules were evaluated by both a Western blotting analysis and reverse transcriptase-polymerase chain reaction (RT-PCR). The histologic inflammation and fibrosis were significantly improved in the group administered poly P in both the DSS and TNBS colitis models. The levels of interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) were significantly decreased by poly P treatment. The expression levels of TGF-β1 and collagens in the colitis mice were decreased by poly P. The LPS-induced expressions of IL-1β and TGF-β1 in Caco-2/BBE cells and of TNF-α in THP-1 cells were reduced by poly P treatment. Poly P did not affect the expression of collagens and connective tissue growth factor in the CCD-18 cells. In conclusion, poly P suppresses intestinal inflammation and fibrosis by downregulating the expression of inflammation- and fibrosis-associated molecules in the intestinal epithelium. The administration of poly P is therefore a novel option to treat fibrosis because of chronic intestinal inflammation. |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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25761132 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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673 |
6178.pdf (754.7 kB)
